2. Gene
  3. XPNPEP2 - X-prolyl aminopeptidase 2 Gene

XPNPEP2 - X-prolyl aminopeptidase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：X-脯氨酰氨肽酶 2

种属: Homo sapiens

同用名: APP2; AEACEI

基因 ID: 7512 | 基因类型: protein coding

关于 XPNPEP2

Cytogenetic location: Xq26.1 Genomic coordinates (GRCh38): X:129,738,979-129,769,536 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues, 7 paralogues and is associated with 2 phenotypes. Biased expression in small intestine (RPKM 88.3), kidney (RPKM 85.4) and 1 other tissue.

功能概要

氨基肽酶 P 是一种对 N 末端亚氨基键具有特异性的水解酶，它对几种胶原蛋白降解产物、神经肽、血管活性肽和细胞因子很常见。在结构上，该酶是“pita bread fold”家族的成员，以可溶性和 GPI 锚定膜结合形式存在于哺乳动物组织中。这种酶的膜结合和可溶形式已被确定为两个独立基因的产物。[RefSeq 提供，2008 年 7 月]

Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several Collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]

XPNPEP2 基因产物(1)

mRNA Protein Name
NM_003399.6 NP_003390.4 xaa-Pro aminopeptidase 2 precursor
基因本体论
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular exosome IDA
IDA: 通过直接分析推断
21082674 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

XPNPEP2 蛋白结构

Creatinase_N

Creatinase_N: Creatinase/Prolidase N-terminal domain (54 - 185)

Peptidase_M24

Peptidase_M24: Metallopeptidase family M24 (392 - 575)

  • 0
  • 200
  • 400
  • 600
  • 674 a.a.
蛋白主名 其他名称

xaa-Pro aminopeptidase 2

X-Pro aminopeptidase 2

重组 XPNPEP2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7499 Aminopeptidase P2 Protein, Human (HEK293, His) O43895 (H22-A650) ≥95%

关联疾病

疾病名称 别名
Angioedema Induced By Ace Inhibitors

AEACEI

Angioedema Induced By Ace Inhibitors, Susceptibility To

Susceptibility To Angioedema Induced By Ace Inhibitors

Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioedema

Ace Inhibitor-Related Acquired Angioedema

Acei-Related Acquired Angioedema

Acquired Angioedema With Normal C1 Inhibitor

Acquired Angioedema With Normal C1inh

Raas-Blocker-Induced Angioedema

Raas-Blocker-Induced Angioneurotic Edema

Rae

Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioneurotic Edema

Ae-Acei

Acquired Angioedema
Angioedema

Angioneurotic Oedema

Quincke'S Edema

Angioneurotic Edema

Giant Urticaria
Hereditary Angioedema

Hereditary Angioneurotic Edema

Hereditary Angioedema Type 1

Hane

Angioedema, Hereditary

Hae

Angioedemas, Hereditary

Deficiency Of C1 Esterase Inhibitor

C1 Esterase Inhibitor Deficiency

C1 Inhibitor Deficiency

Familial Angioneurotic Edema

Hereditary Bradykinine-Induced Angioedema

Hereditary Non Histamine-Induced Angioedema

Hae 1

Hae-I

Hereditary Angioneurotic Edema Type 1

Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

Hereditary Angioedema Types I And Ii

Hereditary Angioneurotic Oedema

Familial Angioedema

Hae - [Hereditary Angioneurotic Oedema]

Bannister Disease, Hereditary

Quincke Disease Or Oedema

Hereditary Quincke Oedema
Pleuropneumonia
Epilepsy, Familial Temporal Lobe, 2

Familial Temporal Lobe Epilepsy 2

Temporal Epilepsy, Familial

ETL2

Ftle

Epilepsy, Familial Temporal Lobe

Familial Temporal Lobe Epilepsy
Nivelon-Nivelon-Mabille Syndrome

Chondrodysplasia-Pseudohermaphroditism Syndrome

NNMS

Chondrodysplasia-Disorder Of Sex Development Syndrome

Nivelon Nivelon Mabille Syndrome
Atrophic Rhinitis

Rhinitis, Atrophic

Ozena

Rhinitis Sicca

Dry Rhinitis

Ozaena
Iminoglycinuria

Iminoglycinuria, Digenic

IG
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15887 XPNPEP2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18585 Xpnpep2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25070 Xpnpep2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus XPNPEP2 VGNC VGNC:36995
Mus musculus XPNPEP2 MGD MGI:2180001
Rattus norvegicus XPNPEP2 RGD RGD:621277
Felis catus XPNPEP2 VGNC VGNC:67111
Canis familiaris XPNPEP2 VGNC VGNC:48458
Macaca mulatta XPNPEP2 VGNC VGNC:78811
Others XPNPEP2 NCBI
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