2. Gene
  3. Srebf1 - sterol regulatory element binding transcription factor 1 Gene

Srebf1 - sterol regulatory element binding transcription factor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: ADD1; ADD-1; Srebp1; SREBP-1; SREBP-1c

基因 ID: 78968 | 基因类型: protein coding

关于 Srebf1

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including response to peptide hormone; response to progesterone; and response to retinoic acid. Located in nucleus. Part of protein-containing complex. Biomarker of alcoholic hepatitis; diabetic neuropathy; kidney disease; lipid storage disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in disease of metabolism and type 2 diabetes mellitus. Orthologous to human SREBF1 (sterol regulatory element binding transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Srebf1 基因产物(2)

mRNA Protein Name
NM_001276707.1 NP_001263636.1 sterol regulatory element-binding protein 1 isoform 1 precursor
NM_001276708.1 NP_001263637.1 sterol regulatory element-binding protein 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
16407292 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16407292 RGD
enables chromatin binding IDA
IDA: 通过直接分析推断
19371623 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
19158095 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
9786926 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to fatty acid IEP
IEP: 通过表达模式推断
19332540 RGD
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
10207099 RGD
involved in cellular response to starvation IDA
IDA: 通过直接分析推断
16407292 RGD
involved in cholesterol metabolic process IMP
IMP: 通过突变表型推断
18071061 RGD
involved in lung development IEP
IEP: 通过表达模式推断
12896875 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
10207099 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16407292 RGD
involved in regulation of lipid storage IEP
IEP: 通过表达模式推断
27939985 RGD
involved in response to cAMP IEP
IEP: 通过表达模式推断
10207099 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
27939985 RGD
involved in response to fatty acid IEP
IEP: 通过表达模式推断
16222032 RGD
involved in response to food IEP
IEP: 通过表达模式推断
19357831 RGD
involved in response to fructose IEP
IEP: 通过表达模式推断
11934685 RGD
involved in response to glucagon IEP
IEP: 通过表达模式推断
10207099 RGD
involved in response to lipid IEP
IEP: 通过表达模式推断
12421847 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
26394137 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
19371623 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
18801905 RGD
involved in response to progesterone IEP
IEP: 通过表达模式推断
11278421 RGD
involved in response to retinoic acid IEP
IEP: 通过表达模式推断
9121491 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
17526932 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein-containing complex IDA
IDA: 通过直接分析推断
19158095 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sterol regulatory element-binding protein 1

adipocyte determination- and differentiation-dependent factor 1

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13757 SREBF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS17721 Srebf1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS24186 Srebf1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS29460 SREBF1 Pig Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Srebf1 NCBI NCBI:6720
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