2. Gene
  3. Hsd17b4 - hydroxysteroid (17-beta) dehydrogenase 4 Gene

Hsd17b4 - hydroxysteroid (17-beta) dehydrogenase 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: MFP-2; MPF-2

基因 ID: 79244 | 基因类型: protein coding

关于 Hsd17b4

功能概要

Enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity; 3-hydroxyacyl-CoA dehydratase activity; and identical protein binding activity. Involved in several processes, including aging; cellular response to organic cyclic compound; and response to steroid hormone. Located in peroxisome. Biomarker of hypertension. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). [provided by Alliance of Genome Resources, Apr 2022]

Hsd17b4 基因产物(1)

mRNA Protein Name
NM_024392.2 NP_077368.2 peroxisomal multifunctional enzyme type 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity IDA
IDA: 通过直接分析推断
9084892 RGD
enables 3-hydroxyacyl-CoA dehydratase activity IDA
IDA: 通过直接分析推断
8902630 RGD
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
IDA: 通过直接分析推断
12225901 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20566640 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to organic cyclic compound IEP
IEP: 通过表达模式推断
12706301 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
16038268 RGD
involved in response to steroid hormone IEP
IEP: 通过表达模式推断
25603467 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
9209713 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in peroxisome IDA
IDA: 通过直接分析推断
14561759 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

peroxisomal multifunctional enzyme type 2

17-beta-HSD 4

17-beta-hydroxysteroid dehydrogenase 4

D-bifunctional protein

DBP

MFE-2

multifunctional protein 2

peroxisomal multifunctional enzyme type II

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120897 NS-3-008 hydrochloride Inhibitor 99.67% 否
HY-RS06397 HSD17B4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS20632 Hsd17b4 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS27141 Hsd17b4 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hsd17b4 NCBI NCBI:3295
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