ZFHX4 - zinc finger homeobox 4 Gene

中文名称：锌指同源盒 4

种属: Homo sapiens

同用名: ZFH4; ZHF4

基因 ID: 79776 | 基因类型: protein coding

关于 ZFHX4

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:76,681,247-76,867,281 (from NCBI)

This gene has 14 transcripts (splice variants), 207 orthologues, 20 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 2.1), adrenal (RPKM 2.1) and 16 other tissues.

功能概要

预测可实现 DNA 结合转录因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。预计参与 RNA 聚合酶 II 的转录调控。预测是染色质的一部分。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZFHX4 基因产物(2)

mRNA	Protein	Name
NM_001410934.1	NP_001397863.1	zinc finger homeobox protein 4 isoform 2
NM_024721.5	NP_078997.4	zinc finger homeobox protein 4 isoform 1

ZFHX4 蛋白结构

zf-C2H2

zf-met

zf-C2H2

Homeobox

0
600
1200
1800
2400
3000
3616 a.a.

蛋白主名

其他名称

zinc finger homeobox protein 4

zinc-finger homeodomain protein 4

关联疾病

疾病名称

别名

Ptosis, Hereditary Congenital 1

Ptosis, Hereditary Congenital, 1	PTOS1
Ptosis, Hereditary Congenital, Type 1

Congenital Ptosis

Congenital Blepharoptosis

Congenital Eyelid Ptosis

Marcus Gunn Phenomenon

Jaw-Winking Syndrome	Marcus-Gunn Syndrome
Jaw-Winking	Maxillopalpebral Synkinesis
Abnormal Innervation Syndrome Of Eyelid	Jaw-Blinking
Pterygoid-Levator Synkinesis	Familial Marcus Gunn Phenomenon
Marcus Gunn Syndrome	Mandibulo-Palpebral Synkinesis-Ptosis Syndrome
Marcus-Gunn Phenomenon

Ptosis

Blepharoptosis	Drooping Eyelid
Droopy Eyelid	Ptosis Of Eyelid
Paralysis Of Levator Palpebrae Superioris

Chromosome 8q21.11 Deletion Syndrome

8q21.11 Microdeletion Syndrome	Del(8)(Q21.11)
Deletion 8q21.11	Monosomy 8q21.11

Peters-Plus Syndrome

Krause-Kivlin Syndrome	Peters Plus Syndrome
Peters Anomaly	Irido-Corneo-Trabecular Dysgenesis
PTRPLS	Peters Anomaly With Short-Limb Dwarfism
Peters Anomaly-Short Limb Dwarfism Syndrome	Peters Anomaly With Short Limb Dwarfism
Peters Congenital Glaucoma	Krause-Van Schooneveld-Kivlin Syndrome
Peters' Plus Syndrome	Peters'-Plus Syndrome
Anomaly Peters

Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome	Duane'S Syndrome
Duane Syndrome	Isolated Duane Retraction Syndrome
Co-Contractive Retraction Syndrome	Duane Anomaly, Isolated
Ocular Retraction Syndrome	Drs
Durs

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16037	ZFHX4 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	ZFHX4	VGNC	VGNC:67229
Canis familiaris	ZFHX4	VGNC	VGNC:48608
Rattus norvegicus	ZFHX4	RGD	RGD:1563022
Macaca mulatta	ZFHX4	VGNC	VGNC:79902
Mus musculus	ZFHX4	MGD	MGI:2137668
Bos taurus	ZFHX4	VGNC	VGNC:37158

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