1. Gene
  2. VASH2 - vasohibin 2 Gene

VASH2 - vasohibin 2 Gene

中文名称:血管抑制素 2

种属: Homo sapiens

基因 ID: 79805 | 基因类型: protein coding

关于 VASH2

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,950,541-212,991,585 (from NCBI)

This gene has 12 transcripts (splice variants), 200 orthologues and 1 paralogue. Broad expression in testis (RPKM 1.7), esophagus (RPKM 1.3) and 20 other tissues.

功能概要

启用肌动蛋白结合活动;金属羧肽酶活性;和微管结合活性。参与轴突发育和蛋白水解。作用于细胞-细胞融合的上游或内部;血管生成的正向调节;和内皮细胞增殖的正调节。位于细胞质中。 [由基因组资源联盟提供,2022 年 4 月]

Enables actin binding activity; metallocarboxypeptidase activity; and microtubule binding activity. Involved in axon development and proteolysis. Acts upstream of or within cell-cell fusion; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

VASH2 基因产物(4)

mRNA Protein Name
NM_001136474.3 NP_001129946.1 tubulinyl-Tyr carboxypeptidase 2 isoform 2
NM_001136475.3 NP_001129947.1 tubulinyl-Tyr carboxypeptidase 2 isoform 3
NM_001301056.2 NP_001287985.1 tubulinyl-Tyr carboxypeptidase 2 isoform 4
NM_024749.5 NP_079025.2 tubulinyl-Tyr carboxypeptidase 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin binding IDA
IDA: 通过直接分析推断
29146869 GOA
enables metallocarboxypeptidase activity IDA
IDA: 通过直接分析推断
29146869 GOA
enables metallocarboxypeptidase activity IMP
IMP: 通过突变表型推断
31171830 GOA
enables microtubule binding IDA
IDA: 通过直接分析推断
31324789 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
29146869 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axon development IMP
IMP: 通过突变表型推断
31324789 GOA
acts upstream of or within cell-cell fusion IDA
IDA: 通过直接分析推断
25184477 GOA
acts upstream of or within cell-cell fusion IMP
IMP: 通过突变表型推断
25184477 GOA
acts upstream of or within positive regulation of angiogenesis IDA
IDA: 通过直接分析推断
19204325 GOA
acts upstream of or within positive regulation of endothelial cell proliferation IDA
IDA: 通过直接分析推断
19204325 GOA
involved in proteolysis IDA
IDA: 通过直接分析推断
29146869 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19204325 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

VASH2 蛋白结构

Vasohibin

Vasohibin: Vasohibin (46 - 291)

  • 0
  • 100
  • 200
  • 300
  • 355 a.a.
蛋白主名 其他名称

tubulinyl-Tyr carboxypeptidase 2

testicular tissue protein Li 222

直系同源

种属 基因名 来源 基因 ID
Mus musculus VASH2 MGD MGI:2444826
Bos taurus VASH2 VGNC VGNC:36768
Rattus norvegicus VASH2 RGD RGD:1564105
Felis catus VASH2 VGNC VGNC:81206
Macaca mulatta VASH2 VGNC VGNC:79532
Canis familiaris VASH2 VGNC VGNC:48234