2. Gene
  3. Git1 - GIT ArfGAP 1 Gene

Git1 - GIT ArfGAP 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 83709 | 基因类型: protein coding

关于 Git1

功能概要

Enables GTPase activator activity; identical protein binding activity; and small GTPase binding activity. A structural constituent of postsynaptic specialization. Involved in several processes, including cellular response to epidermal growth factor stimulus; neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of signal transduction. Acts upstream of or within dendritic spine development and immunological synapse formation. Located in several cellular components, including cytosol; endosome; and neuron projection. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human GIT1 (GIT ArfGAP 1). [provided by Alliance of Genome Resources, Apr 2022]

Git1 基因产物(1)

mRNA Protein Name
NM_031814.2 NP_114002.1 ARF GTPase-activating protein GIT1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IDA
IDA: 通过直接分析推断
9826657 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15212761 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12473661 RGD
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
12629171 RGD
enables protein tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
12629171 RGD
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
12629171 RGD
enables small GTPase binding IDA
IDA: 通过直接分析推断
9826657 RGD
enables structural constituent of postsynaptic specialization IDA
IDA: 通过直接分析推断
25284783 RGD
enables structural constituent of postsynaptic specialization IMP
IMP: 通过突变表型推断
25284783 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to epidermal growth factor stimulus IDA
IDA: 通过直接分析推断
18523162 RGD
acts upstream of or within dendritic spine development IGI
IGI: 通过遗传相互作用推断
17310244 RGD
acts upstream of or within immunological synapse formation IGI
IGI: 通过遗传相互作用推断
17310244 RGD
involved in negative regulation of ARF protein signal transduction IDA
IDA: 通过直接分析推断
16439353 RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
25284783 RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: 通过突变表型推断
25284783 RGD
involved in positive regulation of receptor catabolic process IMP
IMP: 通过突变表型推断
18523162 RGD
involved in regulation of G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
9826657 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
25284783 RGD
is active in GABA-ergic synapse IMP
IMP: 通过突变表型推断
25284783 RGD
located in dendrite IDA
IDA: 通过直接分析推断
12629171 RGD
located in endosome IDA
IDA: 通过直接分析推断
18523162 RGD
located in excitatory synapse IDA
IDA: 通过直接分析推断
12629171 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
25284783 RGD
located in growth cone IDA
IDA: 通过直接分析推断
12629171 RGD
located in inhibitory synapse IDA
IDA: 通过直接分析推断
12629171 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
25284783 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ARF GTPase-activating protein GIT1

ARF GAP GIT1

CAT-1

CAT1

G protein-coupled receptor kinase interacting ArfGAP 1

G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein (GIT1)

G protein-coupled receptor kinase-interactor 1

GRK-interacting prote

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-152095 PPI-GIT1/β-Pix PPI-IN-1 Inhibitor 99.01% 否
HY-RS05438 GIT1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19605 Git1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26101 Git1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Git1 NCBI NCBI:28964
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