2. Gene
  3. SNX25 - sorting nexin 25 Gene

SNX25 - sorting nexin 25 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：分选 nexin 25

种属: Homo sapiens

同用名: SBBI31; MSTP043

基因 ID: 83891 | 基因类型: protein coding

关于 SNX25

This gene has 8 transcripts (splice variants), 209 orthologues and 3 paralogues. Broad expression in lung (RPKM 10.3), thyroid (RPKM 5.9) and 24 other tissues.

功能概要

预计可启用 I 型转化生长因子 β 受体结合活性。参与通路限制性 SMAD 蛋白磷酸化的负调控；转化生长因子β受体信号通路的负调控；和受体分解代谢过程。位于细胞内膜界的细胞器中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable type I transforming growth factor beta receptor binding activity. Involved in negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; and receptor catabolic process. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]

SNX25 基因产物(9)

mRNA Protein Name
NM_001317781.2 NP_001304710.1 sorting nexin-25 isoform 6
NM_001378032.2 NP_001364961.1 sorting nexin-25 isoform 1
NM_001378034.2 NP_001364963.1 sorting nexin-25 isoform 2
NM_001378035.2 NP_001364964.1 sorting nexin-25 isoform 3
NM_001378036.2 NP_001364965.1 sorting nexin-25 isoform 4
NM_001378037.2 NP_001364966.1 sorting nexin-25 isoform 5
NM_001378038.2 NP_001364967.1 sorting nexin-25 isoform 7
NM_001378039.2 NP_001364968.1 sorting nexin-25 isoform 8
NM_001378040.2 NP_001364969.1 sorting nexin-25 isoform 9
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
21266196 GOA
involved in receptor catabolic process IMP
IMP: 通过突变表型推断
21266196 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNX25 蛋白结构

PXA

PXA: PXA domain (2 - 159)

RGS

RGS: Regulator of G protein signaling domain (287 - 400)

PX

PX: PX domain (522 - 624)

Nexin_C

Nexin_C: Sorting nexin C terminal (701 - 806)

  • 0
  • 200
  • 400
  • 600
  • 840 a.a.
蛋白主名 其他名称

sorting nexin-25

关联疾病

疾病名称 别名
Spinocerebellar Ataxia, Autosomal Recessive 20

Autosomal Recessive Spinocerebellar Ataxia 20

SCAR20

Intellectual Disability-Coarse Face-Macrocephaly-Cerebellar Hypotrophy Syndrome

Autosomal Recessive Spinocerebellar Ataxia Type 20

Intellectual Disability-Coarse Face-Macrocephaly-Cerebellar Hypoplasia Syndrome

Spinocerebellar Ataxia, Autosomal Recessive, 20

Ataxia, Spinocerebellar, Autosomal Recessive, Type 20
Intellectual Developmental Disorder, Autosomal Dominant 38

Psychomotor Retardation, Epilepsy, And Language Disability Syndrome

MRD38

Prelds

Autosomal Dominant Non-Syndromic Intellectual Disability 38

Mental Retardation, Autosomal Dominant 38

Autosomal Dominant Intellectual Developmental Disorder 38

Autosomal Dominant Mental Retardation 38

Mental Retardation, Autosomal Dominant, Type 38
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13536 SNX25 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SNX25 RGD RGD:1310150
Macaca mulatta SNX25 VGNC VGNC:77757
Canis familiaris SNX25 VGNC VGNC:46633
Mus musculus SNX25 MGD MGI:2142610
Bos taurus SNX25 VGNC VGNC:35104
Felis catus SNX25 VGNC VGNC:65552
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