2. Gene
  3. TNFRSF14 - TNF receptor superfamily member 14 Gene

TNFRSF14 - TNF receptor superfamily member 14 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TNF 受体超家族成员 14

种属: Homo sapiens

同用名: TR2; ATAR; HVEA; HVEM; CD270; LIGHTR

基因 ID: 8764 | 基因类型: protein coding

关于 TNFRSF14

Cytogenetic location: 1p36.32 Genomic coordinates (GRCh38): 1:2,554,234-2,563,829 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 538 orthologues, 21 paralogues and is associated with 66 phenotypes. Ubiquitous expression in spleen (RPKM 22.9), duodenum (RPKM 21.7) and 23 other tissues.

功能概要

该基因编码 TNF (肿瘤坏死因子) 受体超家族的成员。编码的蛋白质在激活炎症和抑制性 T 细胞免疫反应的信号转导通路中发挥作用。它结合单纯疱疹病毒 (HSV) 病毒包膜糖蛋白 D (gD) ，介导其进入细胞。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 7 月]

This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

TNFRSF14 基因产物(2)

mRNA Protein Name
NM_001297605.2 NP_001284534.1 tumor necrosis factor receptor superfamily member 14 isoform 2 precursor
NM_003820.4 NP_003811.2 tumor necrosis factor receptor superfamily member 14 isoform 1 precursor

TNFRSF14 蛋白结构

TNFR_c6

TNFR_c6: TNFR/NGFR cysteine-rich region (78 - 119)

  • 0
  • 100
  • 200
  • 283 a.a.
蛋白主名 其他名称

tumor necrosis factor receptor superfamily member 14

CD40-like protein

重组 TNFRSF14 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7366 HVEM/TNFRSF14 Protein, Human (Sf9, Fc) Q92956 (L39-K184) ≥95%
HY-P70489 HVEM/TNFRSF14 Protein, Human (164a.a, HEK293, His) Q92956 (L39-V202) ≥95%
HY-P73106 HVEM/TNFRSF14 Protein, Human (202a.a, HEK293, His) Q92956 (M1-V202) ≥95%
HY-P73107 HVEM/TNFRSF14 Protein, Human (HEK293, His-Fc) Q92956 (M1-V202) ≥95%
HY-P78798 HVEM/TNFRSF14 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q92956 (L39-V202) ≥95%
HY-P700452 HVEM/TNFRSF14 Protein, Human (HEK293, hFc) Q92956 (L39-V202) ≥95%

关联疾病

疾病名称 别名
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Ezb Diffuse Large B-Cell Lymphoma

Ezb Dlbcl

Doid:0081065
Herpetic Whitlow

Herpetic Felon
Genital Herpes

Herpes Genitalis

Genital Herpes Simplex

Venereal Herpes

Virus-Genital Herpes
Acute Retinal Necrosis Syndrome

Acute Retinal Necrosis

Retinal Necrosis Syndrome, Acute
Nodal Marginal Zone Lymphoma

Mucosa-Associated Lymphoid Tissue Lymphoma

Monocytoid B-Cell Lymphoma
Type 1 Diabetes Mellitus 21

Diabetes Mellitus, Insulin-Dependent, 21

Iddm21

T1D21

Insulin-Dependent Diabetes Mellitus 21
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14806 TNFRSF14 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TNFRSF14 VGNC VGNC:80387
Macaca mulatta TNFRSF14 VGNC VGNC:78585
Canis familiaris TNFRSF14 VGNC VGNC:47658
Rattus norvegicus TNFRSF14 RGD RGD:1310115
Mus musculus TNFRSF14 MGD MGI:2675303
Others TNFRSF14 NCBI
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