2. Gene
  3. CHD1L - chromodomain helicase DNA binding protein 1 like Gene

CHD1L - chromodomain helicase DNA binding protein 1 like Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：染色质结构域解旋酶 DNA 结合蛋白 1 样

种属: Homo sapiens

同用名: ALC1; CHDL

基因 ID: 9557 | 基因类型: protein coding

关于 CHD1L

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:147,172,747-147,295,762 (from NCBI)

This gene has 33 transcripts (splice variants), 196 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 10.4) and 25 other tissues.

功能概要

该基因编码参与 DNA 修复的 DNA 解旋酶蛋白。该蛋白质将 ATP 转化为添加聚 (ADP-核糖) ，因为它调节 DNA 损伤后的染色质松弛。该基因的过度表达与多种类型的癌症有关。[RefSeq 提供，2017 年 2 月]

This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Overexpression of this gene has been linked to several types of cancers. [provided by RefSeq, Feb 2017]

CHD1L 基因产物(21)

mRNA Protein Name
NM_001256336.3 NP_001243265.1 chromodomain-helicase-DNA-binding protein 1-like isoform 2
NM_001256337.3 NP_001243266.1 chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001256338.3 NP_001243267.1 chromodomain-helicase-DNA-binding protein 1-like isoform 5
NM_001348451.2 NP_001335380.1 chromodomain-helicase-DNA-binding protein 1-like isoform 6
NM_001348452.2 NP_001335381.1 chromodomain-helicase-DNA-binding protein 1-like isoform 6
NM_001348453.2 NP_001335382.1 chromodomain-helicase-DNA-binding protein 1-like isoform 3
NM_001348454.2 NP_001335383.1 chromodomain-helicase-DNA-binding protein 1-like isoform 8
NM_001348455.2 NP_001335384.1 chromodomain-helicase-DNA-binding protein 1-like isoform 9
NM_001348456.2 NP_001335385.1 chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348457.2 NP_001335386.1 chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348458.2 NP_001335387.1 chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348459.2 NP_001335388.1 chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348460.2 NP_001335389.1 chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348461.2 NP_001335390.1 chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348462.2 NP_001335391.1 chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348463.2 NP_001335392.1 chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348464.2 NP_001335393.1 chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348465.2 NP_001335394.1 chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_001348466.2 NP_001335395.1 chromodomain-helicase-DNA-binding protein 1-like isoform 4
NM_004284.6 NP_004275.4 chromodomain-helicase-DNA-binding protein 1-like isoform 1
NM_024568.4 NP_078844.2 chromodomain-helicase-DNA-binding protein 1-like isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP hydrolysis activity IMP
IMP: 通过突变表型推断
19661379 GOA
enables ATP-dependent chromatin remodeler activity IDA
IDA: 通过直接分析推断
29220652 GOA
enables histone reader activity IDA
IDA: 通过直接分析推断
34874266 GOA
enables nucleosome binding IDA
IDA: 通过直接分析推断
33357431 GOA
enables nucleotide binding IDA
IDA: 通过直接分析推断
19661379 GOA
enables poly-ADP-D-ribose modification-dependent protein binding IDA
IDA: 通过直接分析推断
29220652 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19661379 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
19661379 GOA
involved in DNA repair IDA
IDA: 通过直接分析推断
34486521 GOA
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
19661379 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
19661379 GOA
is active in site of DNA damage IDA
IDA: 通过直接分析推断
34486521 GOA
is active in site of double-strand break IDA
IDA: 通过直接分析推断
29220652 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHD1L 蛋白结构

SNF2_N

SNF2_N: SNF2 family N-terminal domain (49 - 328)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (383 - 459)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 897 a.a.
蛋白主名 其他名称

chromodomain-helicase-DNA-binding protein 1-like

amplified in liver cancer 1

重组 CHD1L 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71588 CHD1L Protein, Human (His-SUMO) Q86WJ1 (S704-P897) ≥95%

CHD1L 抗体

目录号 产品名 应用 反应物种
HY-P82491 CHD1L Antibody (YA2236) WB, IHC-P, ICC/IF, IP, FC Human, Mouse

关联疾病

疾病名称 别名
Postcholecystectomy Syndrome

Post Cholecystectomy Syndrome
Thrombophlebitis Migrans
Cakut

Renal Or Urinary Tract Malformation

Congenital Anomalies Of Kidney And Urinary Tract

Congenital Anomaly Of Kidney And Urinary Tract

Congenital Anomalies Of The Kidney And Urinary Tract

Kidney And Urinary Tract, Anomalies, Congenital

Renal Hypodysplasia, Nonsyndromic, 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-144256 CHD1Li 6.11 Inhibitor 99.54% 否
HY-RS02606 CHD1L Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17654 Chd1l Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24114 Chd1l Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CHD1L VGNC VGNC:71027
Rattus norvegicus CHD1L RGD RGD:1311935
Canis familiaris CHD1L VGNC VGNC:49732
Felis catus CHD1L VGNC VGNC:60843
Mus musculus CHD1L MGD MGI:1915308
Bos taurus CHD1L VGNC VGNC:27277
Others CHD1L NCBI
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