2. Gene
  3. TRAM2 - translocation associated membrane protein 2 Gene

TRAM2 - translocation associated membrane protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：易位相关膜蛋白 2

种属: Homo sapiens

基因 ID: 9697 | 基因类型: protein coding

关于 TRAM2

Cytogenetic location: 6p12.2 Genomic coordinates (GRCh38): 6:52,497,408-52,577,060 (from NCBI)

This gene has 1 transcript (splice variant), 206 orthologues and 2 paralogues. Broad expression in placenta (RPKM 12.1), testis (RPKM 6.9) and 23 other tissues.

功能概要

TRAM2 是转运子的一个组成部分，转运子是一个门控大分子通道，它控制内质网 (ER) 膜上新生分泌蛋白和膜蛋白的翻译后加工。[OMIM 提供，2004 年 7 月]

TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]

TRAM2 基因产物(1)

mRNA Protein Name
NM_012288.4 NP_036420.1 translocating chain-associated membrane protein 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14749390 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in collagen biosynthetic process IMP
IMP: 通过突变表型推断
14749390 GOA
involved in protein insertion into ER membrane IDA
IDA: 通过直接分析推断
27499293 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRAM2 蛋白结构

TRAM1

TRAM1: TRAM1-like protein (48 - 111)

TRAM_LAG1_CLN8

TRAM_LAG1_CLN8: TLC domain (113 - 311)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
蛋白主名 其他名称

translocating chain-associated membrane protein 2

TRAM-like protein

关联疾病

疾病名称 别名
Epilepsy, Myoclonic Juvenile

Juvenile Myoclonic Epilepsy

Janz Syndrome

Jme

Myoclonic Epilepsy, Juvenile, Susceptibility To, 1

EJM

Myoclonic Epilepsy, Juvenile

Petit Mal, Impulsive

Myoclonic Epilepsy, Juvenile 1

Myoclonic Epilepsy, Juvenile, 1

Adolescent Myoclonic Epilepsy

Juvenile Myoclonus Epilepsy

Juvenile Myoclonic Epilepsy 1

EJM1

Petit Mal Impulsive

Susceptibility To Juvenile Myoclonic Epilepsy 1

Myoclonic Epilepsy Juvenile

Epilepsy, Myoclonic, Juvenile

Myoclonic Epilepsy Of Janz

Jme - [Juvenile Myoclonic Epilepsy]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14982 TRAM2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS22875 Tram2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS29389 Tram2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TRAM2 VGNC VGNC:54242
Rattus norvegicus TRAM2 RGD RGD:1589151
Macaca mulatta TRAM2 VGNC VGNC:83515
Felis catus TRAM2 VGNC VGNC:102540
Canis familiaris TRAM2 VGNC VGNC:49104
Mus musculus TRAM2 MGD MGI:1924817
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