2. Metabolic Enzyme/Protease
  3. GGTase
  4. GGTI-2133 TFA

GGTI-2133 TFA 是一种肽模拟物，是一种选择性香叶基香叶基转移酶 I (GGTase-I) 抑制剂，IC50 为 38 nM。GGTI-2133 TFA 对 GGTase-I 的选择性是法呢基转移酶 (FTase) 的 140 倍 (IC50 为 5.4 μM)。GGTI-2133 TFA 抑制 Rap-1A 的香叶基化，IC50 为 10 μM。GGTI-2133 TFA 可用于研究嗜酸性粒细胞性气道炎症，例如哮喘。

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GGTI-2133 TFA Chemical Structure

GGTI-2133 TFA Chemical Structure

CAS No. : 1217480-14-2

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GGTI-2133 TFA 的其他形式现货产品:

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GGTI-2133 TFA 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GGTI-2133 TFA, a peptidomimetic, is a selective geranylgeranyltransferase I (GGTase-I) inhibitor with an IC50 of 38 nM. GGTI-2133 TFA shows 140-fold selectivity over farnesyltransferase (FTase) (IC50 of 5.4 μM). GGTI-2133 TFA inhibits the geranylation of Rap-1A with an IC50 of 10 μM. GGTI-2133 TFA can be used for the study of eosinophilic airway inflammation such as asthma[1][2].

体内研究
(In Vivo)

GGTI-2133 (5 mg/kg；腹膜内注射；每日一次；连续 10 天) TFA 可抑制小鼠实验性哮喘中炎症细胞向气道的浸润[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice (8 weeks of age) were actively sensitized byintraperitoneal injections of 8 ug ovalbumin with 2 mg Imject Alum on days 0 and 5[2].
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; once a day; for 10 days from Day 11 to Day 20
Result: Inhibited the antigen-induced eosinophil infiltration into airways almost completely.
分子量

570.56

Formula

C29H29F3N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GGTI-2133 TFA 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GGTI-21331217480-14-2GGTI2133GGTI 2133GGTaseGeranylgeranyl TransferasepeptidomimeticGGTase-IasthmaInhibitorinhibitorinhibit

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