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  3. Ginisortamab

Ginisortamab  (Synonyms: UCB6114)

目录号: HY-P99643 纯度: 99.05%
COA 技术支持

Ginisortamab (UCB6114) 是一种全人源 IgG4P 抗 Gremlin-1 单克隆抗体, 对人类和小鼠 gremlin-1 的平均 IC50 值分别为 8.2 nM 和 9 nM。Ginisortamab 可抑制 Gremlin-1 对 BMP 信号通路的拮抗作用。Ginisortamab 有望用于胃肠道 (GI) 肿瘤研究。

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CAS No. : 2390147-17-6

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1 mg ¥3200
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ginisortamab (UCB6114) is a fully human IgG4P anti Gremlin-1 monoclonal antibody, with mean IC50 values of 8.2 nM and 9 nM against human and mouse gremlin-1, respectivly. Ginisortamab inhibits gremlin-1 antagonism of BMP signaling pathways. Ginisortamab has the potential for the research of gastrointestinal (GI) tumors[1][2][3].

同型

Human IgG4 kappa

推荐同型对照抗体
种属

Human

体外研究
(In Vitro)

Ginisortamab (0.1-1000 nM) 以浓度依赖性方式抑制人类和小鼠 gremlin-1,平均 IC50 值分别为 8.2 nM 和 9 nM[2]
Ginisortamab 对人类和小鼠 gremlin-1 的几何平均亲和力 (平衡解离常数 [KD]) 分别为 87 pM 和 61 pM[2]
Ginisortamab (150 nM,30-120 分钟) 在人类结直肠癌细胞系 (CRC) 和成纤维细胞中抑制 gremlin-1 对 BMP 信号通路的拮抗作用[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

147.56 kDa

同用名

UCB6114

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized Human Gremlin/GREM1 Protein, His Tag can bind Ginisortamab. The EC50 for this effect is 10.22 ng/mL.
纯度 & 产品资料

纯度: 99.05%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Ginisortamab
目录号:
HY-P99643
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