Ginisortamab  (Synonyms: UCB6114)

Ginisortamab (UCB6114) is a fully human IgG4P anti Gremlin-1 monoclonal antibody, with mean IC₅₀ values of 8.2 nM and 9 nM against human and mouse gremlin-1, respectivly. Ginisortamab inhibits gremlin-1 antagonism of BMP signaling pathways. Ginisortamab has the potential for the research of gastrointestinal (GI) tumors^[1][2][3].

Human IgG4 kappa

Human IgG4 (S228P) kappa, Isotype Control

Human

Ginisortamab (0.1-1000 nM) 以浓度依赖性方式抑制人类和小鼠 gremlin-1，平均 IC₅₀ 值分别为 8.2 nM 和 9 nM^[2]。
Ginisortamab 对人类和小鼠 gremlin-1 的几何平均亲和力 (平衡解离常数 [K_D]) 分别为 87 pM 和 61 pM^[2]。
Ginisortamab (150 nM，30-120 分钟) 在人类结直肠癌细胞系 (CRC) 和成纤维细胞中抑制 gremlin-1 对 BMP 信号通路的拮抗作用^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

147.56 kDa

UCB6114

2390147-17-6

液体

Colorless to light yellow

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

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  Human IgG4 kappa

• 
  Immobilized Human Gremlin/GREM1 Protein, His Tag can bind Ginisortamab. The EC₅₀ for this effect is 10.22 ng/mL.

• [1]. Debashis Sarker, et al. A multi-modular phase I/II study of UCB6114, a first-in-class, fully human IgG4P anti-Gremlin-1 monoclonal antibody, as monotherapy and in combination with mFOLFOX6 or trifluridine/tipiracil, for patients with advanced gastrointestinal (GI) tumors. Meeting Abstract, 2022 ASCO Gastrointestinal Cancers Symposium.

  [2]. Davies GCG, et al. Discovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer. MAbs. 2023 Jan-Dec;15(1):2289681.  [Content Brief]

  [3]. Debashis Sarker, et al. Abstract CT094: Phase I dose-escalation study evaluating the safety and tolerability of ginisortamab (UCB6114), a first-in-class anti-gremlin-1 monoclonal antibody (mAb), as monotherapy in advanced solid tumors. Cancer Res (2023) 83 (8_Supplement): CT094 .