2. Immunology/Inflammation
  3. Glycoprotein VI
  4. ACT017

ACT017  (Synonyms: 格仑西单抗)

目录号: HY-P99644 纯度: 99.00%
COA 技术支持

ACT017 是人源化抗 GPVI 单克隆抗体的 Fab 片段。ACT017 抑制胶原诱导的血小板聚集。ACT017 具有研究急性缺血性脑卒中的潜力。

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CAS No. : 2101829-58-5

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规格 价格 是否有货 数量
1 mg ￥2500
In-stock
5 mg ￥6800
In-stock
10 mg ￥10020
In-stock
25 mg ￥14760
In-stock
50 mg ￥20040
In-stock
100 mg   询价  
200 mg   询价  

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ACT017 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ACT017 is a Fab fragment of humanized anti-GPVI monoclonal antibody. ACT017 inhibits collagen-induced platelet aggregation. ACT017 has the potential for the research of acute ischemic stroke[1][2].

体外研究
(In Vitro)

ACT017 (0-100000 ng/mL) 抑制 GPVI-Fc 与固定在微量滴定板上的胶原蛋白结合，IC50 为 1.37 μg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ACT017 相关抗体:
体内研究
(In Vivo)

ACT017 (1-8 mg/kg; i.v.) 抑制食蟹猴中胶原诱导的血小板聚集[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys[2]
Dosage: 1-8 mg/kg
Administration: I.v.
Result: Reversibly inhibited collagen-induced platelet aggregation, at 2 to 8 mg/kg doses, collagen-induced platelet aggregation measured 0.5 hour after the end of the administration was fully inhibited for all cynomolgus.
Clinical Trial
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

48.29 kDa

同用名

格仑西单抗

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

格仑西单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Fab-G1-kappa
Biological Activity
  • Immobilized GPVI Protein, Human can bind Glenzocimab. The EC50 for this effect is 7.19 ng/mL.
纯度 & 产品资料

纯度: 99.00%

COA (265 KB) SDS-PAGE (86 KB) SEC-HPLC (144 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

ACT017 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ACT0172101829-58-5格仑西单抗ACT 017ACT-017Glycoprotein VIGPVIInhibitorinhibitorinhibit

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