2. Apoptosis
  3. Apoptosis
  4. hCAIX-IN-13

hCAIX-IN-13 (Pt2) 是 CAIX (arbonic anhydrase IX) 的抑制剂，IC50 值为 6.57 μM。hCAIX-IN-13 对癌细胞具有细胞毒性，诱导细胞凋亡，可用于癌症的研究。

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hCAIX-IN-13 Chemical Structure

hCAIX-IN-13 Chemical Structure

CAS No. : 2813334-66-4

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hCAIX-IN-13 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hCAIX-IN-13 (Pt2) is an inhibitor of CAIX (arbonic anhydrase IX) with an IC50 value of 6.57 μM. hCAIX-IN-13 inhibits growth of cancer cells and induces cell apoptosis, it can be used for the research of cancer[1].

IC50 & Target

IC50: 6.57 μM (CAIX)[1]
体外研究
(In Vitro)

hCAIX-IN-13 (10 and 20 μM; 24 h) effectively attenuates extracellular acidification through the inhibited activity of the cellular CAIX expression[1].
hCAIX-IN-13 (20 and 40 μM; 24 h) affects CAIX expression[1].
hCAIX-IN-13 (0-200 μM; 24 h) shows high cytotoxicity to cancer cell lines[1].
hCAIX-IN-13 (5-15 μM; 24 h) promotes the production of cellular ROS[1].
hCAIX-IN-13 (5-20 μM; 48 h) induces cell apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

hCAIX-IN-13 相关抗体:

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cell line
Concentration: 20 and 40 μM
Incubation Time: 24 hours
Result: Dose-dependently inhibited the expression level of cellular CAIX.

Cell Cytotoxicity Assay[1]

Cell Line: Hela, A549, MDA-MB 231, HLF and LO2 cell lines
Concentration: 0-200 μM
Incubation Time: 48 hours
Result: Showed cytotoxicity to Hela, A549, MDA-MB 231, normal cell HLF and normal cell LO2 with IC50s of 31.64, 30.45, 12.67, 21.64 and ＞100 μM, respectively.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cell line
Concentration: 5-20 μM
Incubation Time: 48 hours
Result: Dose-dependently induced the early apoptotic stage.
分子量

989.90

Formula

C37H33F3N6O7PtS2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hCAIX-IN-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAIX-IN-132813334-66-4Apoptosiscisplatinacidificationcellular environmentNIRcomplexlysosomeHelaROSMDA-MB 231apoptosisInhibitorinhibitorinhibit

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产品名称：
hCAIX-IN-13
目录号：
HY-151406
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