1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
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  3. HER2-targeted peptide H6F

HER2-targeted peptide H6F 是一种 HER2 靶向肽,通过与 HER2 结合靶向乳腺癌细胞,氨基酸序列为 YLFFVFER。HER2-targeted peptide H6F 能够与双功能螯合剂水杨酰胺 (HYNIC) 偶联,用于与 99mTc 结合进行放射性标记。单光子发射计算机断层扫描 (SPECT) 成像显示,标记后的 HER2-targeted peptide H6F 能够特异性地在HER2阳性的 MDA-MBA-453 肿瘤小鼠模型中积累。HER2-targeted peptide H6F 可用于肿瘤分子影像学研究。

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HER2-targeted peptide H6F Chemical Structure

HER2-targeted peptide H6F Chemical Structure

CAS No. : 1644155-35-0

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  • 生物活性

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生物活性

HER2-targeted peptide H6F is a HER2 targeting peptide that binds to HER2 to target breast cancer cells, with the amino acid sequence YLFFVFER. The HER2-targeted peptide H6F can be conjugated with the bifunctional chelating agent hydrazinonicotinamide (HYNIC) for radiolabeling with 99mTc. Single-photon emission computed tomography (SPECT) imaging shows that the labeled HER2-targeted peptide H6F specifically accumulates in HER2-positive MDA-MBA-453 tumor-bearing mice models. The HER2-targeted peptide H6F can be used for tumor molecular imaging studies[1].

IC50 & Target

HER2

 

分子量

1120.30

Formula

C58H77N11O12

CAS 号
Sequence

Tyr-Leu-Phe-Phe-Val-Phe-Glu-Arg

Sequence Shortening

YLFFVFER

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
HER2-targeted peptide H6F
目录号:
HY-P10792
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