2. Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. Aurora Kinase Apoptosis
  4. HLDA-212

HLDA-212 (Compound 43) 是一种靶向 HaloTag-tagged protein (靶蛋白, TP) 和 Aurora kinase A/B (AURKA/B, 效应蛋白, EP) 的双功能小分子化合物。HLDA-212 结合 TP 和 EP，形成稳定的三元复合物 (TP:RIPTAC:EP)，抑制 EP 的细胞存活功能，诱导表达 TP 的癌细胞凋亡 (apoptosis)。HLDA-212 在 293_HFL 细胞中表现出抗增殖活性 (GI50 为 0.011 μM)。HLDA-212 有望用于 TP 高表达的癌症 (如前列腺癌、血液系统恶性肿瘤)。

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HLDA-212 Chemical Structure

HLDA-212 Chemical Structure

CAS No. : 3077339-88-6

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HLDA-212 相关抗体

Top Publications Citing Use of Products

查看 Aurora Kinase 亚型特异性产品:

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Aurora Kinase Aurora A Aurora B Aurora C

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HLDA-212 (Compound 43) is a bifunctional small molecule targeting HaloTag-tagged protein (Target Protein, TP) and Aurora kinase A/B (AURKA/B, Effector Protein, EP). HLDA-212 binds to TP and EP to form a stable ternary complex (TP:RIPTAC:EP), inhibiting the cell-survival function of EP and inducing apoptosis in TP-expressing cancer cells. HLDA-212 shows antiproliferative activity (GI50 of 0.011 μM) in 293_HFL cells. HLDA-212 is promising for research of cancers with high TP expression (such as prostate cancer and hematological malignancies)[1].

IC50 & Target

Aurora A

 

Aurora B

 

分子量

1478.47

Formula

C70H90BrFN8O19S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HLDA-212 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HLDA-2123077339-88-6HLDA212HLDA 212Aurora KinaseApoptosisTPAURKA/BapoptosiscancersInhibitorinhibitorinhibit

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目录号：
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