2. Immunology/Inflammation
  3. Nuclear Factor of activated T Cells (NFAT)
  4. HMBPP lithium

HMBPP lithium  (Synonyms: (E)-4-Hydroxy-3-methyl-but-2-enyl diphosphate lithium)

目录号: HY-134891 纯度: 98.0%
COA 产品使用指南 技术支持

HMBPP lithium 是异戊二烯生物合成的中间体，可由使用非甲羟戊酸途径进行异戊二烯生物合成的细菌和原生动物产生。HMBPP lithium 是 BTN3A1 内部域的配体，是人 Vγ9/Vδ2 T 细胞的激活剂。HMBPP lithium 刺激蚊子的进食行为。

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HMBPP lithium Chemical Structure

HMBPP lithium Chemical Structure

CAS No. : 396726-03-7

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HMBPP lithium 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HMBPP lithium is an intermediate in isoprenoid biosynthesis that can be produced by bacteria and protozoa that use the non-mevalonate pathway for isoprenoid biosynthesis. HMBPP lithium is a ligand of the internal domain of BTN3A1 and is an activator for human Vγ9/Vδ2 T cells. HMBPP lithium exhibits phagostimulant property in mosquitos[1][2][3][4].

体外研究
(In Vitro)

HMBPP (10 μM) lithium 可刺激主要蚊子媒介 (HMBPP 补充的红细胞) 中的蚊子进食行为[2]。
HMBPP (10 μM, 12 小时) lithium 可激活人属纯化的 γδ T 细胞，并在 γδ T 细胞与 GBM 细胞 (U251、U373 和原代 GBM 培养物) 孵育时增加 CD69、细胞内穿孔素、IFN-γ 和 TNF-α 的产生[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HMBPP lithium 相关抗体:
体内研究
(In Vivo)

HMBPP (50 mg/kg，肌肉注射) lithium 联合 IL-2 (皮下注射，100 万 units，每天一次，连续 5 天) 在吸入性鼠疫耶尔森菌感染期间诱导食蟹猴肺中诱导 Vγ2Vδ2 T 效应细胞的长期积累[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Macaques infected with Y.pestis, 5 hours after inhalational Y.pestis infection, the macaques received HMBPP plus IL-2[5]
Dosage: 50 mg/kg
Administration: i.m., plus IL-2 (s.c., 1 million unit, once daily for 5 days)
Result: Induced Vγ2Vδ2 T cell accumulation localized in pulmonary interstitials surrounding bloodvessels and airway mucosa in the lung tissues with no or mildplague lesions.
Attenuated inhalation plague lesions in lungs.
分子量

279.89

同用名

(E)-4-Hydroxy-3-methyl-but-2-enyl diphosphate lithium

Formula

C5H9Li3O8P2
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

Escherichia coli
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

纯度: 98.0%

COA (282 KB)

产品使用指南 (1538 KB)
参考文献

HMBPP lithium 相关分类

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Keywords:

HMBPP396726-03-7(E)-4-Hydroxy-3-methyl-but-2-enyl diphosphateNuclear Factor of activated T Cells (NFAT)MosquitophagostimulantAnopheles coluzziiAn. arabiensisAn. gambiae s.s.Aedes aegyptiCulex pipiensCulex torrentiumInhibitorinhibitorinhibit

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