2. Immunology/Inflammation
  3. Interleukin Related
  4. Hydrocortisone hemisuccinate

Hydrocortisone hemisuccinate  (Synonyms: Hydrocortisone 21-hemisuccinate)

目录号: HY-B1402G
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Hydrocortisone hemisuccinate GMP (Hydrocortisone 21-hemisuccinate GMP) 是 GMP 级别的Hydrocortisone hemisuccinate (HY-B1402)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate)，一种糖皮质激素，是口服活性的甾体抗炎剂 (SAID)，具有抗炎和免疫调节活性。Hydrocortisone hemisuccinate 抑制 IL-6 和 IL-3 的生物活性，IC50 值分别为 6.7 和 21.4 μM。Hydrocortisone hemisuccinate 可用于溃疡性结肠炎 (UC) 和复发性口疮的研究。。

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Hydrocortisone hemisuccinate Chemical Structure

Hydrocortisone hemisuccinate Chemical Structure

CAS No. : 2203-97-6

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Hydrocortisone hemisuccinate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hydrocortisone hemisuccinate GMP (Hydrocortisone 21-hemisuccinate GMP) is a GMP-grade version of Hydrocortisone hemisuccinate (HY-B1402). GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate inhibits the bioactivity of IL-6 and IL-3 with IC50 values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers[1][2][3]. [1].

体外研究
(In Vitro)

Hydrocortisone hemisuccinate 抑制 IL-6 和 IL-3 的生物活性，IC50 分别为 6.7 和 21.4 μM，对非 IL-6 依赖性的 MH60 细胞无细胞毒性作用[3]。
Hydrocortisone hemisuccinate (0.12-60 μM; 72 小时) 抑制外周淋巴细胞 (PBL) 和 T 淋巴细胞培养中的植物血凝素 (PHA) 反应[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hydrocortisone hemisuccinate 相关抗体:
体内研究
(In Vivo)

Hydrocortisone hemisuccinate (30 mg/kg, p.o.; 每日 2 次，共 5 天) 减轻了小鼠体重的减轻，并增加了进食量[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis[2]
Dosage: 30 mg/kg
Administration: P.o. twice daily for 5 days
Result: Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group.
Increased the body weight.
分子量

462.53

同用名

Hydrocortisone 21-hemisuccinate

Formula

C25H34O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hydrocortisone hemisuccinate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydrocortisone hemisuccinate (GMP)2203-97-6Hydrocortisone 21-hemisuccinate (GMP)Interleukin RelatedILsteroidalanti-in ammatorySAID,proinflammatorycytokineIL-6IL-3ulcerativecolitisUCInhibitorinhibitorinhibit

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