2. Immunology/Inflammation
  3. Interleukin Related
  4. IL17A-IN-1

IL17A-IN-1 (化合物 72) 是一种口服有效的 Interleukin 17A 抑制剂。IL17A-IN-1 可用于炎症和自身免疫性疾病，如斑块状银屑病、银屑病关节炎和强直性脊柱炎等，以及癌症的研究。

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IL17A-IN-1 Chemical Structure

IL17A-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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IL17A-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IL17A-IN-1 (compound 72) is an orally active Interleukin 17A inhibitor. IL17A-IN-1 can be used in the study of inflammatory and autoimmune diseases (plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis, etc.), as well as cancer[1].

体外研究
(In Vitro)

IL17A-IN-1 抑制 Hela 细胞的 IC50 值为 0.005 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IL17A-IN-1 相关抗体:
体内研究
(In Vivo)

IL17A-IN-1 (10 mg/kg; p.o.; single dose) 可抑制 hIL17A 诱导小鼠 (含有 IL17 受体的小鼠) CXCL1 PD 模型中血浆 CXCL1 的分泌[1]。(小鼠皮下注射重组人 IL17A 能诱导血浆 CXCL1 分泌)。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (hIL17A-induced mouse CXCL1 PD model)[1].
Dosage: 10 mg/kg
Administration: Oral administration; single dose
Result: Inhibited 53% of CXCL1 secretion in hIL17A-induced mouse CXCL1 PD model.
Animal Model: Male Sprague-Dawley rats; 360-460 g[1].
Dosage: 0.3 mg/kg
Administration: Intravenous injection; single dose
Result: 1.19 Pharmacokinetic Parameters of IL17A-IN-1 in male Sprague-Dawley rats[1].
IV (0.3 mg/kg)
Vss (L/kg) 5.0
t1/2 (h) 3.6
CLp/CLp,u (L/h/kg) 1.1/6.1
分子量

612.55

Formula

C30H35Cl2N7O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IL17A-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IL17A-IN-1Interleukin RelatedILHelaplaque psoriasispsoriatic arthritisankylosing spondylitiscancertumorautoimmuneinflammationInhibitorinhibitorinhibit

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产品名称：
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目录号：
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