2. Immunology/Inflammation Apoptosis
  3. IRAK Apoptosis
  4. IRAK4-IN-27

IRAK4-IN-27 (Compound 22) 是一种有效的、选择性的 IRAK4 抑制剂，IC50 为 8.7 nM。IRAK4-IN-27 抑制 MYD88 L265P DLBCL 细胞系细胞生长，促进细胞凋亡 (apoptosis)。IRAK4-IN-27 可用于弥漫大 b 细胞淋巴瘤研究。

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IRAK4-IN-27 Chemical Structure

IRAK4-IN-27 Chemical Structure

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IRAK4-IN-27 相关抗体

Top Publications Citing Use of Products

查看 IRAK 亚型特异性产品:

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IRAK1 IRAK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IRAK4-IN-27 (Compound 22) is a potent, selective inhibitor of IRAK4, with IC50 of 8.7 nM. IRAK4-IN-27 inhibits cell growth, and promotes apoptosis in MYD88 L265P diffuse large B-cell lymphoma (DLBCL) cell line. IRAK4-IN-27 can be used for DLBCL study[1].

IC50 & Target

IRAK4

8.7 nM (IC50)

体外研究
(In Vitro)

IRAK4-IN-27 (Compound 22, 72 h) 对 MYD88 L265P DLBCL 细胞株 (OCI-LY10, IC50 = 0.248 μM)和 MYD88 野生型细胞株 (U2932, IC50 = 1.251 μM, 和 GM00637, IC50 = 1.520 μM) 均表现出抗增殖活性[1]。
IRAK4-IN-27 (0.5 μM 和 1 μM, 24 和 48 h) 诱导 OCI-LY10 细胞凋亡[1]。
IRAK4- in -27 (0.03-3 μM) 抑制 OCI-LY10 细胞中 IRAK4 磷酸化和下游信号通路[1]。
IRAK4-IN-27 (0.1 μM 和 0.2 μM, 48 h) 联合 Ibrutinib (HY-10997) 抑制 OCI-LY10 细胞生长，诱导细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IRAK4-IN-27 相关抗体:

Apoptosis Analysis[1]

Cell Line: OCI-LY10 cells
Concentration: 0, 0.1, 0.2, 0.5, 1 μM
Incubation Time: 24 and 48 h
Result: Triggered significant apoptosis after 24 h incubation, with apoptosis rates of 48.3% and 66.8% at the concentration of 0.5 μM and 1 μM, respectively.
Induced apoptosis of 67.2% and 92.3% after 48 h incubation at the concentration of 0.5 μM and 1 μM, respectively.
分子量

430.46

Formula

C23H22N6O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IRAK4-IN-27 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRAK4-IN-27IRAKApoptosisInterleukin-1 receptor associated kinaseIL-1R associated kinasediffuse large B-cell lymphomaOCI-LY10U2932GM00637apoptosisInhibitorinhibitorinhibit

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目录号：
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