2. Apoptosis
  3. Apoptosis
  4. Isodispar B

Isodispar B 是一种抗癌剂，抑制鼻咽癌和乳腺癌细胞增殖，诱导细胞凋亡 (apoptosis)。Isodispar B 对广泛的癌细胞系具有细胞毒性。

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Isodispar B Chemical Structure

Isodispar B Chemical Structure

CAS No. : 98192-64-4

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Isodispar B 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
KB IC50
4 μg/mL
Compound: 23
Cytotoxicity against human KB cells assessed as inhibition of cell growth incubated for 72 hrs by neutral red dye based colorimetric assay
Cytotoxicity against human KB cells assessed as inhibition of cell growth incubated for 72 hrs by neutral red dye based colorimetric assay
[PMID: 27494166]
体外研究
(In Vitro)

Isodispar B (化合物 1) (0-100 μM; 72 h) 具有广谱的抗癌活性，抑制细胞增殖，IC50 为 3.84-56.73 μM[1]。
Isodispar B (1 μM 和 10 μM; 3 d) 诱导鼻咽癌细胞 (TW01、CNE1、HK1、SUNE1) 凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Isodispar B 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Nasopharyngeal cancer cells (TW01, CNE1, HK1, and SUNE1) and noncancerous nasopharyngeal cells (NP460)
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Showed cytotoxicity and inhibited cell viability with IC50s of 3.84 μM (SUNE1), 11.49 μM (TW01), 9.74 μM (CNE1), 5.58 μM (HK1), 56.73 μM (HCC38), 52.69 μM (MDA-MB-231), 52.75 μM (MDA-ME-468), and 54.85 μM (SKBR3), respectively.
分子量

338.35

Formula

C20H18O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Isodispar B 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isodispar B98192-64-4ApoptosisInhibitorinhibitorinhibit

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