2. Others
  3. Isotope-Labeled Compounds
  4. Ivosidenib-d5

Ivosidenib-d5  (Synonyms: 艾伏尼布-d5; AG-120-d5)

目录号: HY-18767S3
产品使用指南 技术支持

Ivosidenib-d5 (AG-120-d5) 是氘代标记的 Ivosidenib. Ivosidenib (AG-120) 是异柠檬酸脱氢酶 1 的突变体酶 (mIDH1 enzyme) 的口服活性抑制剂，它使 d-2- hydroxyglutatrate (2-HG) 在体内降低。Ivosidenib 具有良好的的安全性和临床活性，具有 AML 研究的潜力。

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Ivosidenib-d<sub>5</sub> Chemical Structure

Ivosidenib-d5 Chemical Structure

CAS No. : 2329582-02-5

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Other Forms of Ivosidenib-d5:

Ivosidenib-d5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ivosidenib-d5 (AG-120-d5) is deuterium labeled Ivosidenib. Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity[1].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ivosidenib-d5 相关抗体:
分子量

587.99

Formula

C28H17D5ClF3N6O3
CAS 号
非标记 CAS
中文名称

艾伏尼布-d5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ivosidenib-d5 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ivosidenib-d52329582-02-5AG-120-d5艾伏尼布-d5Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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