2. Peptides
  3. KLD-12

KLD-12 是一种 12 个残基的自组装肽，可用于组织工程。KLD-12 和 SDF-1 形成自组装多肽，促进骨髓基质细胞 (BMSC) 的软骨分化。KLD-12 水凝胶可以原位填充全层骨软骨缺损，改善软骨修复。

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Custom Peptide Synthesis

KLD-12 Chemical Structure

KLD-12 Chemical Structure

CAS No. : 800379-47-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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KLD-12 的其他形式现货产品:

Customer Review

Other Forms of KLD-12:

KLD-12 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KLD-12 is a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair[1][2][3].

体外研究
(In Vitro)

KLD-12 与 SDF-1 形成自组装多肽，提高骨髓基质细胞 (BMSC) 的存活率，通过 Wnt/β-catenin 通路促进 BMSC 成骨分化和细胞迁移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KLD-12 相关抗体:
体内研究
(In Vivo)

KLD-12 TFA (10-250 μg/rat，单剂量，骨折部位注射) 在股骨钻孔损伤的 Sprague-Dawley 大鼠模型中，剂量依赖地促进骨折部位的骨再生[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats model with drill-hole injury in femur[2]
Dosage: 10-250 μg/rat
Administration: injection to the fracture site, single dose
Result: Increased osteoinduction and callus formation.
分子量

1467.79

Formula

C68H122N16O19
CAS 号
Sequence

Ac-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-NH2
Sequence Shortening

Ac-KLDLKLDLKLDL-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KLD-12800379-47-9KLD12KLD 12Othersself-assemblingchondrogenicdifferentiationBMSCsosteochondraldefectscartilagerepairSprague-Dawley ratsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-P2263
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