2. Anti-infection
  3. HCV SARS-CoV
  4. Ledipasvir hydrochloride

Ledipasvir hydrochloride  (Synonyms: GS-5885 hydrochloride)

目录号: HY-15602C
产品使用指南

摩尔计算器

Ledipasvir (GS-5885) hydrochloride 是一种有效的 HCV NS5A 抑制剂，能够抑制 GT1a 和 GT1b 复制子，EC50 值分别为 34 pM 和 4 pM。Ledipasvir hydrochloride 也是 SARS-CoV 3CLpro 的抑制剂，IC50 为 1.62 μM。

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Ledipasvir hydrochloride Chemical Structure

Ledipasvir hydrochloride Chemical Structure

CAS No. : 2128695-48-5

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Ledipasvir hydrochloride 的其他形式现货产品:

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Ledipasvir hydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 27 篇科研文献

WB

    Ledipasvir hydrochloride purchased from MCE. Usage Cited in: Antimicrob Agents Chemother. 2015 Jun;59(6):3482-92.  [Abstract]

    Assessment of HCV inhibition by DAAs from 3 classes using Western blot analysis. Jc1/Gluc2A virus-infected Huh-7.5.1 cells are treated with DMSO or the HCV inhibitors at concentrations of 100× EC50 (DCV, 3.2 nM; LDV, 3 μM; DNV, 0.32 μM; SOF, 20 μM). Cell lysates are harvested at 8 hpt (C and D) or at 24 hpt (A and B) and blotted for NS5A (A and C) or core (B and D). Data are normalized to GAPDH and quantified as relative fold change with respect to DMSO.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Ledipasvir (GS-5885) hydrochloride is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir hydrochloride is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.62 μM[3].

    IC50 & Target

    EC50: 34 pM (GT1a), 4 pM (GT1b)[1]
    IC50: 1.62 Μm (SARS-CoV 3CLpro)[3]
    体外研究
    (In Vitro)

    Ledipasvir hydrochloride has GT1a and 1b EC50 values of 31 and 4 pM, respectively, and protein-adjusted EC50 values of 210 pM (GT1a) and 27 pM (GT1b) and the intrinsic EC50 of 39 is 310 fM for GT1a and 40 fM for GT1b. Ledipasvir hydrochloride is highly protein-bound both in human serum and in the cell-culture medium (containing 10% BSA) of the replicon assay[1]. Ledipasvir hydrochloride exhibits an EC50 value of 141 nM against the JFH/3a-NS5A replicon[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Ledipasvir hydrochloride 相关抗体:
    体内研究
    (In Vivo)

    Ledipasvir hydrochloride is remarkable not only on the basis of its high replicon potency but also on the basis of its low clearance, good bioavailability, and long half-lives in rat, dog, and monkey and low predicted clearance in human. The pharmacokinetics of Ledipasvir hydrochloride is measured in rats and dogs. Ledipasvir shows good half-lives (rat 1.83 hr, dog 2.63 hr) in plasma, low systemic clearance (CL), and moderate volumes of distribution (Vss) that are greater than total body water volume[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    925.46

    Formula

    C49H55ClF2N8O6
    CAS 号
    中文名称

    盐酸雷迪帕韦；盐酸来地帕韦
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Ledipasvir hydrochloride 相关分类

    • 摩尔计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ledipasvir2128695-48-5GS-5885盐酸雷迪帕韦盐酸来地帕韦GS5885GS 5885HCVSARS-CoVHepatitis C virusSARS coronavirusHCV NS5ASARS-CoV 3CLproInhibitorinhibitorinhibit

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