2. Membrane Transporter/Ion Channel
  3. Proton Pump
  4. Linaprazan mesylate

Linaprazan mesylate  (Synonyms: 利那拉生甲磺酸盐; AZD-0865 mesylate)

目录号: HY-100412A
产品使用指南 技术支持

Linaprazan (AZD0865) mesylate 能够通过K+竞争约束抑制胃里H+,K+ -ATPase. (IC 50: 1.0 ± 0.2 μM)，它对酸有很强的抑制作用。Linaprazan (AZD0865) mesylate 可用于研究反流性食管炎，具有口服有效性。

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Linaprazan mesylate Chemical Structure

Linaprazan mesylate Chemical Structure

CAS No. : 855998-67-3

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Linaprazan mesylate 的其他形式现货产品:

Customer Review

Other Forms of Linaprazan mesylate:

Linaprazan mesylate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Linaprazan mesylate can inhibit H+,K+ -ATPase in the stomach through K+ competitive binding. (IC 50: 1.0 ± 0.2 μM), it has a strong inhibitory effect on acid. Linaprazan (AZD0865) mesylate can be used for research on reflux esophagitis with oral activity[1][2][3].

体外研究
(In Vitro)

Linaprazan (AZD0865) mesylate 抑制组胺或二丁基 cAMP 刺激的家兔胃腺的酸性形成 (IC50 分别为 0.28 和 0.26 μM)[1]。
Linaprazan (AZD0865) mesylate (3 μM，pH 7.4) 抑制 H+，K+ - ATP 酶活性为 88.1%[1]。
Linaprazan (AZD0865) mesylate 以 K+ 竞争方式抑制 H+，K+ - ATP 酶活性 (Ki=46 nM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Linaprazan mesylate 相关抗体:
体内研究
(In Vivo)


SD大鼠单次口服 2.4 mg/kg 的 Linaprazan mesylate 的药代动力学分析[3]

Sex t1/2 (h) Tmax (h) Cmax (ng eq./g) AUC0-t (ng·h eq./g) AUC0-∞ (ng·h eq./g) AUC% (%)
Male 5.08 4.67 455 5960 6200 4.12
Femal 4.64 4.00 1270 13900 14300 3.10

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

462.56

同用名

利那拉生甲磺酸盐; AZD-0865 mesylate

Formula

C22H30N4O5S
CAS 号
中文名称

利那拉生甲磺酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Linaprazan mesylate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Linaprazan855998-67-3AZD-0865利那拉生甲磺酸盐AZD0865AZD 0865Proton PumpReflux esophagitisH+,K+ -ATPaseInhibitorinhibitorinhibit

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