2. Apoptosis
  3. Ferroptosis
  4. Liproxstatin-1 hydrochloride

Liproxstatin-1 hydrochloride 

目录号: HY-12726A 纯度: 99.31%
COA 产品使用指南 技术支持

Liproxstatin-1 hydrochloride 是一种有效的 ferroptosis 抑制剂，抑制 ferroptotic 细胞死亡 (IC50=22 nM)。

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Liproxstatin-1 hydrochloride Chemical Structure

Liproxstatin-1 hydrochloride Chemical Structure

CAS No. : 2250025-95-5

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规格 价格 是否有货 数量
5 mg ￥1100
In-stock
10 mg ￥1800
In-stock
25 mg ￥2700
In-stock
50 mg ￥3600
In-stock
100 mg ￥5200
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of Liproxstatin-1 hydrochloride:

Liproxstatin-1 hydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 155 篇科研文献

RT-PCR
Cell Viability Assay
WB
Proliferation Assay

    Liproxstatin-1 hydrochloride purchased from MCE. Usage Cited in: Redox Biol. 2024 Nov 5:78:103419.  [Abstract]

    Cell viability of the control NCI–H358, Calu-1, NCI–H23, MIA PaCa-2 and the corresponding resistant cell lines after 24 h of treatment with the indicated compounds. 2 μM liproxstatin-1 (Lip-1), 10 μM sorafenib or 10 μM lapatinib was used to treat NCI–H358, NCI–H23 and MIA PaCa-2 cells, while Calu-1 cells were treated with 2 μM liproxstatin-1 (Lip-1), 3 μM sorafenib or 10 μM lapatinib (n = 3).

    Liproxstatin-1 hydrochloride purchased from MCE. Usage Cited in: Redox Biol. 2024 Dec 5:79:103460.  [Abstract]

    143B and SJSA-1 cells were treated with SFN with or without Lip-1 (1 μM) for 48 h, and cell viability was evaluated.

    Liproxstatin-1 hydrochloride purchased from MCE. Usage Cited in: Theranostics. 2024 Jul 2;14(10):4090-4106.  [Abstract]

    Liproxstatin 1 (Lip-1) (48 h) largely reverses the cytotoxicity of ferroptosis inducers enhanced by p62 knockdown in Hela cells.

    Liproxstatin-1 hydrochloride purchased from MCE. Usage Cited in: J Hazard Mater. 2024 Sep 24:480:135952.  [Abstract]

    Liproxstatin-1 (100 nM; 50 h) alleviates the decrease in O-GlcNAcylation levels and ferroptosis-related proteins in AML12 cells caused by DON (48 h) exposure.

    Liproxstatin-1 hydrochloride purchased from MCE. Usage Cited in: MedComm. 2024 Apr 4;5(4):e520.  [Abstract]

    Antiferroptosis treatment repressed the development of AS in vivo. Normal group: normal diet; HFD group: HFD for 3 months; HFD + ferrostatin‐1 group: HFD accompanied by ferrostatin‐1 treatment (1 mg/kg, twice a day, i.p.); HFD + liproxstatin‐1 group: HFD accompanied by liproxstatin‐1 treatment (10 mg/kg, twice a day, i.p.). IHC of 4‐HEN (ferroptosis marker) in aortic sinus.

    Liproxstatin-1 hydrochloride purchased from MCE. Usage Cited in: Redox Biol. 2024 May 23:73:103207.  [Abstract]

    Cell survival of 5FU-R cells treated with a gradient concentration of PUFAs and 10 μM ferrostatin-1, or 10 μM liproxstatin-1 for 24 h.

    Liproxstatin-1 hydrochloride purchased from MCE. Usage Cited in: Adv Sci (Weinh). 2023 Nov 16:e2303812.  [Abstract]

    Cell viability of HEC-1A cells transfected with sh‐PRMT3 and treated with erastin in the absence or presence of liproxstatin‐1 (400 nM), ZVAD‐FMK (10 µM), 3‐methyladenine (1 mM) or necrosulfonamide (10 µM) for 48 h.

    Liproxstatin-1 hydrochloride purchased from MCE. Usage Cited in: Biomaterials. 2024 Jan, 304, 122430.

    Liproxstatin-1 (1 μM). The concentration-dependent cytotoxicity of LysoCOS7, LysoRaw and LysoNeu in the presence of various inhibitors.

    Liproxstatin-1 hydrochloride purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2019 Nov 5;519(2):240-245.  [Abstract]

    The ROS and inflammatory cytokines levels increase in acute RILI. The serum levels of inflammatory cytokines increase in RILI. Elisa was used to measure the levels of inflammatory cytokines (TNF-a, IL-6, IL-10 and TGF-b1) at day 15, day 30 and day 60.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM)[1].

    体外研究
    (In Vitro)

    Liproxstatin-1 shows antiferroptotic activity with an IC50 of approximately 38 nM in mouse embryonic fibroblasts[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Liproxstatin-1 hydrochloride 相关抗体:
    体内研究
    (In Vivo)

    Liproxstatin-1 (10 mg/kg, i.p.) suppresses ferroptosis in human cells, Gpx4-/- kidney and in an ischaemia/reperfusion-induced tissue injury model[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    377.31

    Formula

    C19H22Cl2N4
    CAS 号
    性状

    固体

    颜色

    Light yellow to brown

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 5.83 mg/mL (15.45 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.6503 mL 13.2517 mL 26.5034 mL
    5 mM 0.5301 mL 2.6503 mL 5.3007 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献

    Liproxstatin-1 hydrochloride 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.6503 mL 13.2517 mL 26.5034 mL 66.2585 mL
    5 mM 0.5301 mL 2.6503 mL 5.3007 mL 13.2517 mL
    10 mM 0.2650 mL 1.3252 mL 2.6503 mL 6.6259 mL
    15 mM 0.1767 mL 0.8834 mL 1.7669 mL 4.4172 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Liproxstatin-12250025-95-5Liproxstatin1Liproxstatin 1FerroptosisInhibitorinhibitorinhibit

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