2. Epigenetics Neuronal Signaling Apoptosis
  3. Histone Demethylase Monoamine Oxidase Apoptosis Bcl-2 Family IAP Caspase
  4. LSD1-IN-26

LSD1-IN-26 (compound 12u) 是一种有效的 LSD1 抑制剂，IC50 为 25.3 nM。 LSD1-IN-26 还抑制 MAO-A (IC50 = 1234.57 nM) 和 MAO-B (IC50 = 3819.27 nM)。 LSD1-IN-26 显著诱导 MGC-803 细胞凋亡 (apoptosis)。LSD1-IN-26可用于胃癌研究。

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LSD1-IN-26 Chemical Structure

LSD1-IN-26 Chemical Structure

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LSD1-IN-26 相关抗体

Top Publications Citing Use of Products

查看 Histone Demethylase 亚型特异性产品:

查看所有亚型
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6

查看 Monoamine Oxidase 亚型特异性产品:

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MAO-A MAO-B

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

查看 IAP 亚型特异性产品:

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cIAP cIAP-1 cIAP-2 XIAP

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LSD1-IN-26 (compound 12u) is a potent LSD1 inhibitor, with an IC50 of 25.3 nM. LSD1-IN-26 also inhibits MAO-A (IC50=1234.57 nM) and MAO-B (IC50=3819.27 nM). LSD1-IN-26 significantly induces apoptosis in MGC-803 cells. LSD1-IN-26 can be used for gastric cancer research[1].

IC50 & Target

LSD1

25.3 ± 1.4 nM (IC50)

MAO-A

1234.57 nM (IC50)

MAO-B

3819.27 nM (IC50)

Bcl-2

 

cIAP-1

 

Caspase-3

 

Caspase-9

 

体外研究
(In Vitro)

LSD1-IN-26 (compound 12u) 对 MGC-803、KYSE450 和 HCT-116 细胞表现出高效作用，IC50 值分别为 14.3±1.18、22.8±1.45 和 16.3±2.22 μM，高于 GSK-LSD1 (HY-100546) (IC50 > 64 μM) 和 GSK-2879552 (HY-18632) (IC50 > 64 μM)[1]。
LSD1-IN-26 (0-24 μM, 48 h) 诱导 H3K4 Me1/2 和 H3K9 Me2/3 的积累以及 Bcl-2 和 c-IAP1 的减少[1]。
LSD1-IN-26 (0-24 μM, 48 h) 诱导细胞凋亡和分化，抑制迁移和细胞干性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LSD1-IN-26 相关抗体:

Western Blot Analysis[1]

Cell Line: MGC-803 cells
Concentration: 0, 8, 16, 24 μM
Incubation Time: 48 h
Result: Effectively up-regulated the substrate proteins of LSD1, thereby significantly increasing the expression levels of mono-/bi-methylation of H3K4 and H3K9. Dose-dependently induced the decrease of expression levels of anti-apoptotic proteins Bcl-2 and c-IAP1, and the cleavage of apoptotic executive proteins Caspase3 and Caspase9.
分子量

516.41

Formula

C27H25Cl2F2N3O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LSD1-IN-26 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1-IN-26Histone DemethylaseMonoamine OxidaseApoptosisBcl-2 FamilyIAPCaspaseMAOanticancerMGC-803KYSE450HCT-116gastric cancerInhibitorinhibitorinhibit

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