2. Apoptosis
  3. c-Myc
  4. Lusianthridin

Lusianthridin 是来自 Dendrobium venustum 的天然化合物，具有抗迁移作用。Lusianthridin 通过抑制Src-STAT3 信号，促进c-Myc 的降解。

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Lusianthridin Chemical Structure

Lusianthridin Chemical Structure

CAS No. : 87530-30-1

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Lusianthridin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 11
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay
[PMID: 27310249]
HeLa IC50
> 10 μM
Compound: 11
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay
[PMID: 27310249]
HSC-T6 IC50
61.2 μM
Compound: 17
Antiproliferative activity against rat HSC-T6 cells after 48 hrs by MTT assay
Antiproliferative activity against rat HSC-T6 cells after 48 hrs by MTT assay
[PMID: 18052323]
MCF7 IC50
> 10 μM
Compound: 11
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay
[PMID: 27310249]
RAW264.7 IC50
4.6 μM
Compound: Lusianthridin
Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay
Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay
[PMID: 29280630]
体外研究
(In Vitro)

Lusianthridin (0-100 μM) inhibits cell viability at concentrations greater than 50 μM in both H460 and H292 cells[1].
Lusianthridin significantly reduces the CSC populations in both H460 and H292 cells of the CSC spheres, with a significant decrease in the size of the H460 CSC spheres by approximately 10%, 63%, and 77% at day 3 at concentration 5, 10, and 20 μM Lusianthridin, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lusianthridin 相关抗体:

Cell Viability Assay[1]

Cell Line: The human non-small cell lung cancer cell lines, NCI-H460, and NCI-H292 cells[1]. 0-100 μM.
Concentration: 0-100 μM.
Incubation Time: 24 h.
Result: Caused a significant reduction in terms of cell viability at concentrations greater than 50 μM in both H460 and H292 cells.
分子量

242.27

Formula

C15H14O3
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥98.0%

COA (263 KB)

产品使用指南 (1538 KB)
参考文献

Lusianthridin 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lusianthridin87530-30-1c-MycMycInhibitorinhibitorinhibit

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