2. Apoptosis Cytoskeleton
  3. Apoptosis MDM-2/p53 Integrin
  4. LVTX-8

LVTX-8 是一种从 Lycosa vittata 中提取的肽毒素。LVTX-8 对肺癌具有强效的抗癌和抗转移活性，且具有强的细胞毒性。LVTX-8 通过 P53 缺氧通路和整合素信号传导显著诱导细胞凋亡 (apoptosis)，并抑制肺癌细胞的增殖、侵袭和迁移。LVTX-8 显著抑制 A549/H460 异种移植小鼠模型中的肿瘤生长和转移。

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Custom Peptide Synthesis

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LVTX-8 Chemical Structure

LVTX-8 Chemical Structure

CAS No. : 2197957-07-4

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规格 是否有货
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LVTX-8 相关抗体

Top Publications Citing Use of Products

查看 Integrin 亚型特异性产品:

查看所有亚型
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LVTX-8 is a peptide toxin, exacted from Lycosa vittata. LVTX-8 has potent anticancer and and anti-metastasis activities towards lung cancer with strong cytotoxicity. LVTX-8 significantly induces apoptosis and inhibits the proliferation, invasion and migration of lung cancer cells through P53 hypoxia pathways and integrin signaling. LVTX-8 significantly inhibits the tumor growth and metastasis in A549/H460 xenograft mice model[1].

分子量

2849.46

Formula

C135H226N36O31
CAS 号
Sequence

Ile-Trp-Leu-Thr-Ala-Leu-Lys-Phe-Leu-Gly-Lys-Asn-Leu-Gly-Lys-His-Leu-Ala-Lys-Gln-Gln-Leu-Ser-Lys-Leu
Sequence Shortening

IWLTALKFLGKNLGKHLAKQQLSKL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LVTX-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LVTX-82197957-07-4LVTX8LVTX 8ApoptosisMDM-2/p53IntegrinPeptide toxinLycosa vittataAnti-metastasisAnticancerA549 cellsH460 cellsA549/H460 xenograft mice modelLung cancerInhibitorinhibitorinhibit

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目录号：
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