2. Metabolic Enzyme/Protease
  3. MAGL
  4. MAGL-IN-12

SAR127303 是一种口服活性、选择性、竞争性单酰甘油脂肪酶 (MAGL) 共价抑制剂，对小鼠和人 MAGL 的 IC50 值分别为 3.8 nM 和 29 nM。SAR127303 可有效提高小鼠海马中 2-AG 的水平。SAR127303 降低海马 CA1 突触传递和乙酰胆碱释放的长时程增强 (LTP)。SAR127303 在炎症和内脏疼痛测定中产生抗伤害作用。SAR127303 减缓癫痫发生。

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MAGL-IN-12 Chemical Structure

MAGL-IN-12 Chemical Structure

CAS No. : 1352011-38-1

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MAGL-IN-12 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SAR127303 is an orally active, selective, competitive monoacylglycerol lipase (MAGL) covalent inhibitor with IC50s of 3.8 nM and 29 nM for mouse and human MAGL, respectively. SAR127303 potently elevates hippocampal levels of 2-AG in mice. SAR127303 decreased long term potentiation (LTP) of CA1 synaptic transmission and acetylcholine release in the hippocampus. SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain. SAR127303 slows down epileptogenesis[1].

分子量

482.83

Formula

C16H17ClF6N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAGL-IN-12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAGL-IN-121352011-38-1MAGLMonoacylglycerol lipaseOrallymonoacylglycerol lipasehippocampal2-AGlong term potentiationLTPCA1acetylcholineantinociceptiveinflammatoryvisceral painepileptogenesisInhibitorinhibitorinhibit

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产品名称：
MAGL-IN-12
目录号：
HY-116143
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