2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. MC-Val-Ala-NHS ester

MC-Val-Ala-NHS 酯是一种可裂解的 ADC 连接子，具有马来酰亚胺基团和 NHS 酯基团。Val-Ala 接头可被组织蛋白酶 B 裂解。马来酰亚胺基团可与硫醇基团反应。MC 可与硫醇部分反应。NHS 酯能够在中性或弱碱性条件下与胺（例如赖氨酸残基的侧链或氨基硅烷涂层表面）特异性且高效地反应，形成共价键。试剂级，仅供研究使用。

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MC-Val-Ala-NHS ester Chemical Structure

MC-Val-Ala-NHS ester Chemical Structure

CAS No. : 1895916-22-9

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MC-Val-Ala-NHS ester 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

生物活性

MC-Val-Ala-NHS ester is a cleavable ADC linker with a malimide group and an NHS ester group. The Val-Ala linkers can be cleaved by Cathepsin B. Maleimide group is reactive toward thiol groups. MC is reactive with thiol moieties. The NHS ester is able to react specifically and efficiently with amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond.

分子量

478.50

Formula

C22H30N4O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

MC-Val-Ala-NHS ester 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

MC-Val-Ala-NHS ester1895916-22-9ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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