2. Academic Validation
  3. One-Pot Assembly of Unsymmetrical Biaryl Thioglycosides through Chemoselective Palladium-Catalyzed Three-Component Tandem Reaction

One-Pot Assembly of Unsymmetrical Biaryl Thioglycosides through Chemoselective Palladium-Catalyzed Three-Component Tandem Reaction

  • Org Lett. 2018 Jul 6;20(13):4067-4071. doi: 10.1021/acs.orglett.8b01624.
Sara Benmahdjoub 1 2,  Nada Ibrahim 1,  Belkacem Benmerad 2,  Mouad Alami 1,  Samir Messaoudi 1
Affiliations

Affiliations

  • 1 BioCIS, Univ. Paris-Sud, CNRS , University Paris-Saclay , Châtenay-Malabry , France.
  • 2 Laboratoire de Physico-Chimie des Matériaux et Catalyse, Faculté des Sciences Exactes , Université de Bejaia , 06000 Bejaia , Algeria.
PMID: 29927256 DOI: 10.1021/acs.orglett.8b01624
Abstract

A range of unsymmetrical biaryls bearing thiosugars could be synthesized in a one-pot multicomponent approach using one catalytic palladium system that permitted the C-S and C-C bonds to be formed sequentially. The reaction showed a high selectivity and was applied to a broad variety of substrates giving access to novel glycosylated biaryl structures in good yields.

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