2. Academic Validation
  3. Polymyxin derivatives as broad-spectrum antibiotic agents

Polymyxin derivatives as broad-spectrum antibiotic agents

  • Chem Commun (Camb). 2019 Oct 29;55(87):13104-13107. doi: 10.1039/c9cc06908a.
Ma Su 1,  Minghui Wang 1,  Yuzhu Hong 2,  Alekhya Nimmagadda 1,  Ning Shen 2,  Yan Shi 1,  Ruixuan Gao 1,  En Zhang 3,  Chuanhai Cao 2,  Jianfeng Cai 1
Affiliations

Affiliations

  • 1 Department of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu.
  • 2 College of Pharmacy, University of South Florida, Tampa, FL 33620, USA. ccao@health.usf.edu.
  • 3 Department of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, P. R. China.
PMID: 31612170 DOI: 10.1039/c9cc06908a
Abstract

We designed a few polymyxin derivatives which exhibit broad-spectrum antimicrobial activity. Lead compound P1 could disrupt Bacterial membranes rapidly without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in an MRSA-infected thigh burden mouse model.

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