1. Academic Validation
  2. Biocompatible and photocrosslinkable poly(ethylene glycol)/keratin biocomposite hydrogels

Biocompatible and photocrosslinkable poly(ethylene glycol)/keratin biocomposite hydrogels

  • J Biomater Sci Polym Ed. 2021 Oct;32(15):1998-2008. doi: 10.1080/09205063.2021.1952384.
Chenshu Wang 1 Lijuan Wang 1 Xiuzhen Wan 1 Xuefeng Jiang 1 Jiang Yuan 1
Affiliations

Affiliation

  • 1 Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. China.
Abstract

A biocompatible hydrogel is ideal for tissue engineering and regeneration. In this study, methacrylated keratin (KerMA) was synthesized for the first time and then blended with poly(ethylene glycol dimethacrylate) (PEGDMA) to form hydrogel through photocrosslinking. The chemical structure, gelation time, swelling behavior, hydrophilicity, cytotoxicity, and 3D printability of PEGDMA/KerMA hydrogels were characterized and exploited. The PEGDMA/KerMA hydrogels performed good cytocompatibility, providing potential applications for tissue engineering and regenerative medicine.

Keywords

Methacrylated keratin; PEGDMA; biocompatibility; hydrogel; photocrosslinking.

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