2. Cell Cycle/DNA Damage MAPK/ERK Pathway
  3. MNK Eukaryotic Initiation Factor (eIF)
  4. MNK1/2-IN-7

MNK1/2-IN-7 (compound 20j) 是一种口服有效的 MNK1/2 的抑制剂，具有抗癌活性和 hERG 安全性。MNK1/2-IN-7 还抑制 eIF4E 的磷酸化，抑制 MNK/eIF4E 信号通路和癌细胞增殖。MNK1/2-IN-7 与 Ibrutinib (HY-109970) 有协同作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

MNK1/2-IN-7 Chemical Structure

MNK1/2-IN-7 Chemical Structure

CAS No. : 2548283-27-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

MNK1/2-IN-7 相关抗体

Top Publications Citing Use of Products

查看 MNK 亚型特异性产品:

查看所有亚型
MNK1 MNK2 MNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MNK1/2-IN-7 (compound 20j) is an orally available inhibitor of MNK1/2 with anticancer activity and hERG safety. MNK1/2-IN-7 also inhibits the phosphorylation of eIF4E, inhibiting the MNK/eIF4E signaling pathway and cancer cell proliferation. MNK1/2-IN-7 is synergistic with Ibrutinib (HY-109970).[15][1].

IC50 & Target

MNK1

4.4 nM (IC50, [1])

MNK2

.4 nM (IC50, [1])

体外研究
(In Vitro)

MNK1/2-IN-7 (1.25-5 μM; 24 h) 抑制 Hela 细胞中 eIF4E 的磷酸化 (IC50=90.5 nM) 并下调 A549 细胞中 eIF4E 和 4E-BP1 的磷酸化[1]。
MNK1/2-IN-7 在人、犬、大鼠的肝脏微粒中表现出稳定性，T1/2 分别为 62.6 min，>120 min，和 64.6 min[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MNK1/2-IN-7 相关抗体:

Western Blot Analysis[1]

Cell Line: A549 cell line
Concentration: 1.25 μM, 2.5 μM, 5 μM
Incubation Time: 24 h
Result: Downregulated the phosphorylation of eIF4E and 4E-BP1.
体内研究
(In Vivo)

MNK1/2-IN-7 (5 mg/kg; po; 单剂量) 在大鼠中表现出可接受的暴露和生物利用度，具有口服有效性[1]。
MNK1/2-IN-7 (10 mg/kg; po; 17 d) 在 DOHH2 的异种异植小鼠模型中，有效使得肿瘤消退，且不影响小鼠体重。MNK1/2-IN-7 还与 Ibrutinib (HY-109970) 有协同作用[1]。

在 SD 大鼠中的药代动力学分析[1]

Route Dose (mg/kg) T1/2 (h) Tmax (h) Cmax (μg/mL) AUC0-t (h·μg/mL) AUC0-∞ (h·μg/mL) Cl (mL/h/kg) F (%)
i.v. 1 13.8 0.083 1.3 10.0 14.4 70.2 /
p.o. 5 >24 6 1.5 23.3 NA / 46.86

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: GCB-DLBCL DOHH2 xenograft tumors model in mouse[1]
Dosage: 10 mg/kg
Administration: po; once daily for 17 days; or combination of 3 mg/kg Ibrutinib
Result: Resulted tumor regression
Achieved a greater TGI value of 54% for combination group at the end of treatment compared to the value for a single administration or ibrutinib administration.
分子量

505.61

Formula

C31H31N5O2
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MNK1/2-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MNK1/2-IN-72548283-27-6MNKEukaryotic Initiation Factor (eIF)Mitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinaseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
MNK1/2-IN-7
目录号：
HY-163479
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z