2. Apoptosis
  3. Apoptosis
  4. MPI-0441138

MPI-0441138 是凋亡 (apoptosis) 诱导剂和有丝分裂抑制剂。MPI-0441138 可诱导 DNA 断裂，诱导细胞色素 c 转位，导致肿瘤细胞死亡。

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MPI-0441138 Chemical Structure

MPI-0441138 Chemical Structure

CAS No. : 827030-33-1

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MPI-0441138 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death[1].

体外研究
(In Vitro)

MPI-0441138 (5 nM；72 h) 诱导 22Rv1、MDA-MB-231、Caco-2 和 Du145 细胞中的细胞凋亡和 DNA 片段化[1]。
MPI-0441138 (5 nM; 1 h) 诱导 AIF 和 细胞色素 c 从线粒体易位至细胞质和细胞核[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MPI-0441138 相关抗体:

Apoptosis Analysis[1]

Cell Line: 22Rv1, MDA-MB-231, Caco-2, and Du145 cells
Concentration: 5 nM
Incubation Time: 12, 24, 48, or 72 h
Result: Resulted robust caspase-3 activation and poly(ADP-ribose) polymerase cleavage, induced DNA fragmentation.
分子量

299.75

Formula

C16H14ClN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MPI-0441138 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPI-0441138827030-33-1MPI0441138MPI 0441138ApoptosisDNA breakagenuclear translocationanti-cancerInhibitorinhibitorinhibit

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目录号：
HY-129715
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