2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis Autophagy
  3. Microtubule/Tubulin Apoptosis Autophagy
  4. Nab-Paclitaxel

Nab-Paclitaxel  (Synonyms: 白蛋白结合型紫杉醇; Nanoparticle albumin-bound Paclitaxel; Nanoparticle albumin-bound ABI-007)

目录号: HY-P99974 纯度: 99.70%
COA 技术支持

Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) 是一种白蛋白结合的紫杉醇纳米颗粒制剂 (HY-B0015)。Nab-Paclitaxel 由白蛋白和活性药物成分紫杉醇组成，其中人血白蛋白作为赋形剂，用于分散和稳定颗粒并承载主要药物。Nab-Paclitaxel 是一种无溶剂紫杉烷，具有更高的反应率和更好的耐受性。Nab-Paclitaxel 毒性更低，抗肿瘤活性更强。Nab-Paclitaxel 在 3 种横纹肌肉瘤细胞系、7 种神经母细胞瘤细胞系和 1 种骨肉瘤细胞系中更容易被肿瘤细胞摄取。Nab-Paclitaxel 可用于癌症研究，例如乳腺癌和实体瘤。(下方产品规格仅指示Paditaxe!有效含量，实际白蛋白质量以批次为准;该产品中各成分比例为Paditaxel:白蛋白-1:7~1:11)。

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Nab-Paclitaxel Chemical Structure

Nab-Paclitaxel Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥350
In-stock
5 mg ￥500
In-stock
10 mg ￥730
In-stock
25 mg ￥1350
In-stock
50 mg ￥2100
In-stock
100 mg ￥3400
In-stock
200 mg   询价  
500 mg   询价  

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Nab-Paclitaxel 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015). Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel, in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug. Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability. Nab-Paclitaxel displays less toxicity and greater antitumor activity. Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma, seven neuroblastoma cell lines, and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors. (The product specifications below only indicate the effective content of Paditaxel, the actual albumin quality depends on the batch; the ratio of each ingredient in this product is Paditaxel: albumin -1:7~1:11)[1][2].

体外研究
(In Vitro)

Nab-Paclitaxel (0.1 nM-10 μM，72 小时) 在 3 种横纹肌肉瘤细胞系、7 种神经母细胞瘤细胞系和 1 种骨肉瘤细胞系中更容易被肿瘤细胞摄取[3]。
Nab-Paclitaxel (12-120 nM，48 小时) 可增加 RH4 细胞凋亡，且在较高浓度 (60 或 120 nM) 下，大多数细胞从盖玻片上脱落[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nab-Paclitaxel 相关抗体:

Cell Cytotoxicity Assay[3]

Cell Line: Three rhabdomyosarcoma cell lines(RH4, RH30, and RD), seven neuroblastoma cell lines (CHLA-20, CHLA-15, CHLA-90, LAN-5, SK-N-BE(2), BE(2)C, and SH-SY5Y) and one osteosarcoma cell line (KHOS)
Concentration: 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM
Incubation Time: 72 h
Result: Reduced the cell viability of the three rhabdomyosarcoma cell lines with IC50 ranging from 0.56 to 4.68 nM.
Exhibited dose-dependent cytotoxicity in seven neuroblastoma cell lines, where CHLA-20 has the highest IC50 of 36 nM.
体内研究
(In Vivo)

Nab-Paclitaxel (30-50 mg/kg，静脉注射，第1、8、15天给药) 显著抑制了横纹肌肉瘤 (RH4 和 RD) 异种移植瘤小鼠的 RH4 肿瘤生长，第 8 天第二次给药后肿瘤消退[3]。
Nab-Paclitaxel (2-10 mg/kg，静脉注射，每日一次) 在 5 和 10 mg/kg 剂量下显著抑制了神经母细胞瘤(SK-N-BE (2) 和 CHLA-20) 异种移植瘤 (皮下) 小鼠的肿瘤生长[3]。
Nab-Paclitaxel (50 mg/kg，静脉注射，每周一次) 具有最强的抗肿瘤活性，并显著延长动物生存期[3]。
Nab-Paclitaxel (10 mg/kg，静脉注射，连续 5 天或 50 mg/kg，静脉注射，每周) 在横纹肌肉瘤和神经母细胞瘤小鼠模型中均显示较低的血浆 Nab-Paclitaxel 浓度，但较高的肿瘤内 Nab-Paclitaxel 浓度[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD/SCID (nonobese diabetic/severe combined immunodeficient) mice 4- to 6-week old bearing rhabdomyosarcoma (RH4 and RD) xenografts[3]
Dosage: 30, 50 mg/kg
Administration: Intravenous injection (i.v.), administer on day 1, 8, 15 then 52, 59, 66
Result: Exhibited lower toxicity to mice compared with Paclitaxel.
Increased local relapse-free intervals.
Significantly inhibited tumor growth and led to tumor shrinkage.
Remained sensitivity in mice with relapse RH4 xenografts against Nab-Paclitaxel whilst the xenografts were drug resistant against Paclitaxel.
Led to complete regression after day 29, but a few had relapsed tumor after 37 to 42 days.
Animal Model: Female NOD/SCID (nonobese diabetic/severe combined immunodeficient) mice 4- to 6-week old bearing rhabdomyosarcoma or neuroblastoma xenografts[3]
Dosage: 10 mg/kg for 5 consecutive days or 50 mg/kg weekly
Administration: Intravenous injection (i.v.)
Result: Significantly increased apoptotic cell population in a dose-dependent manner.
Increased phospho-histone H3-positive cells in a dose-dependent manner.
Induced G2-M cell-cycle arrest.
Clinical Trial
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
同用名

白蛋白结合型紫杉醇; Nanoparticle albumin-bound Paclitaxel; Nanoparticle albumin-bound ABI-007

性状

固体

颜色

White to off-white

中文名称

白蛋白结合型紫杉醇
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.70%

COA (264 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Nab-Paclitaxel 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nab-PaclitaxelNanoparticle albumin-bound Paclitaxel Nanoparticle albumin-bound ABI-007白蛋白结合型紫杉醇Microtubule/TubulinApoptosisAutophagyAlbuminantitumorbreast cancerInhibitorinhibitorinhibit

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