2. GPCR/G Protein Apoptosis Others
  3. Taste Receptor Apoptosis Drug Derivative
  4. Neotame (GMP Like)

Neotame (GMP Like) 是类 GMP 级别的 Neotame (HY-W011053)，可用作药用辅料。Neotame 是 Aspartame (HY-B0361) 的衍生物，是一种风味增强剂和低热量，无营养，高强度的人工甜味剂，比糖甜 7000-13000 倍。Neotame 在较高浓度下可造成肠上皮细胞死亡。Neotame 诱导 Caco-2 细胞凋亡 (Apoptosis)。

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Neotame (GMP Like) Chemical Structure

Neotame (GMP Like) Chemical Structure

CAS No. : 165450-17-9

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Other Forms of Neotame (GMP Like):

Neotame (GMP Like) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neotame (GMP Like) is the GMP Like class Neotame (HY-W011053) that can be used as pharmaceutical excipients. Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells[1][2][3].

体外研究
(In Vitro)

Neotame (GMP Like) (100 μM, 6-24 h) 在高浓度下导致肠上皮细胞死亡，在较低浓度 (1-100 μM) 下通过上皮单层渗漏[3]。
Neotame (GMP Like) (0-1000 μM, 6-24 h) 诱导的体外肠上皮损伤，包括屏障破坏和细胞凋亡，是由甜味受体 T1R3 介导的[3]。
Neotame (GMP Like) (0-100 μM, 24 h) 减少了 Caco-2 细胞表面观察到的 Claudin 3 的表达[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neotame (GMP Like) 相关抗体:

Cell Viability Assay[3]

Cell Line: Caco-2 cells
Concentration: 0, 0.01, 0.1, 1, 10, 100, 1000, 10000 μM
Incubation Time: 24 h
Result: Showed very little cell viability at high concentrations.

Apoptosis Analysis[3]

Cell Line: Caco-2 cells
Concentration: 0, 0.01, 0.1, 1, 10, 100, 1000, 10000 μM
Incubation Time: 6 h
Result: Increased cell death from 100 μM and higher.
Increased significant apoptosis of Caco-2 cells from 10 μM and higher.

Western Blot Analysis[3]

Cell Line: Caco-2 cells
Concentration: 0, 10, 100 μM
Incubation Time: 24 h
Result: Reduced Claudin 3 expression observed at Caco-2 cell surface.
体内研究
(In Vivo)

Neotame (GMP Like) (0.75 mg/kg, p.o., daily, 4 weeks) 的摄入扰乱了雄性 CD-1 小鼠肠道微生物组的多样性和群落组成并且改变了小鼠粪便样本中的代谢物谱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ten male CD-1 mice around 7 weeks old[1].
Dosage: 0.75 mg/kg
Administration: p.o., daily, 4 weeks
Result: Induced lower alpha-diversity of gut microbiome than the control group.
Enriched phylum Bacteroidetes, while decreased Firmicutes.
Induced multiple components of family Lachnospiraceae and family Ruminococcaceae lower than controls, such as Blautia, Dorea, Oscillospira and Ruminococcus.
Enriched amino acid metabolism, LPS biosynthesis, antibiotics biosynthesis and folate biosynthesis pathways.
Induced lower fatty acid metabolism, carbohydrate metabolism, lipid metabolism and ABC transporters than in controls.
Decreased most of the altered metabolites, such as malic acid, mannose-6-phosphate, 5-aminovaleric acid and glyceric acid.
Decreased most of the identified lipids and fatty acids, including 1,3-dipalmitate, 1-monopalmitin, linoleic acid and stearic acid.
Increased the concentrations of cholesterol, campesterol and stigmastanol in the fecal samples.
分子量

378.46

Formula

C20H30N2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neotame (GMP Like) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neotame (GMP Like)165450-17-9Taste ReceptorApoptosisDrug DerivativeDrug derivativeInhibitorinhibitorinhibit

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