2. Anti-infection
  3. Influenza Virus
  4. Neuraminidase-IN-16

Neuraminidase-IN-16 (Compound 43b) 是一种有效的神经氨酸酶 (neuraminidase) 抑制剂，对 H5N1、H5N8、H1N1、H3N2、H5N1-H274Y 和 H1N1-H274Y 的神经氨酸酶抑制作用的 IC50 分别为 0.031、0.15、0.25、0.60、0.63 和 10.08 μM。

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Neuraminidase-IN-16 Chemical Structure

Neuraminidase-IN-16 Chemical Structure

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Neuraminidase-IN-16 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neuraminidase-IN-16 (Compound 43b) is a potent neuraminidase inhibitor with IC50s of 0.031, 0.15, 0.25, 0.60, 0.63 and 10.08 μM against neuraminidase of H5N1, H5N8, H1N1, H3N2, H5N1-H274Y and H1N1-H274Y, respectively[1].

体外研究
(In Vitro)

Neuraminidase-IN-16 (Compound 43b; 48 h) 在鸡胚成纤维细胞 (CEFs) 中对 H5N1 和 H5N8 表现出抗流感病毒活性，EC50 分别为 2.10±0.44 μM 和 2.28±0.67 μM[1]。
Neuraminidase-IN-16 (48 h) 在 MDCK 细胞中对 H1N1 和 H3N2 表现出抗流感病毒活性，EC50 分别为 0.20±0.01 μM 和 11.3±2.5 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neuraminidase-IN-16 相关抗体:
体内研究
(In Vivo)

Neuraminidase-IN-16 (Compound 43b; 0.039-10 mM; 100 uL) 在无特定病原体 (SPF) 鸡胚蛋中显示抗流感病毒活性[1]。
Neuraminidase-IN-16 不能通过血脑屏障[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SPF chicken embryonated egg infected with H5N1 and H5N8 virus strains[1]
Dosage: 0.039, 0.156, 0.625, 2.5 and 10 mM; 100 uL
Administration: A 1 mm diameter hole was drilled into the egg shell on the side where the embryo was located, the mixture was injected into the egg, and the holes were sealed by wax.
Result: Showed 100% protective effect at the highest tested concentration (10 mM).
分子量

458.57

Formula

C26H35FN2O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neuraminidase-IN-16 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuraminidase-IN-16Influenza VirusMDCKCEFsChicken Embryo Fibroblast cellschicken embryonated eggH5N1H5N8H1N1H3N2H5N1–H274YH1N1–H274YInhibitorinhibitorinhibit

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目录号：
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