2. Immunology/Inflammation Apoptosis
  3. Toll-like Receptor (TLR) Apoptosis NO Synthase
  4. ODN 1826 sodium

ODN 1826 sodium  (Synonyms: CpG 1826 sodium)

目录号: HY-146245C 纯度: 99.51%
COA 产品使用指南 技术支持

ODN 1826 sodium 是一种 B 类 CpG ODN (寡脱氧核苷酸)和 TLR9 激动剂。ODN 1826 sodium 诱导 NO 和 iNOS 产生、增强凋亡 (Apoptosis)。ODN 1826 sodium 增强免疫监视。ODN 1826 sodium 增加主动脉粥样硬化斑块大小。ODN 1826 sodium 对肺癌、胶质瘤和黑色素瘤具有抗肿瘤活性。

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DNA, d(P-thio)(T-C-C-A-T-G-A-C-G-T-T-C-C-T-G-A-C-G-T-T), sodium salt

ODN 1826 sodium Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥2640
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Customer Review

Other Forms of ODN 1826 sodium:

ODN 1826 sodium 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

查看 NO Synthase 亚型特异性产品:

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nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ODN 1826 sodium is a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist. ODN 1826 sodium induces NO and iNOS production and enhances Apoptosis. ODN 1826 sodium enhances immune surveillance. ODN 1826 sodium increases aortic atherosclerotic plaque size. ODN 1826 sodium has antitumor activity against lung cancer, glioma and melanoma[1][2][3][4][5][6].

IC50 & Target

TLR9

 

体外研究
(In Vitro)

ODN 1826 (1 μg/mL；24 h) sodium 在 RAW 264.7 小鼠巨噬细胞中诱导一氧化氮 (NO) 和诱导型一氧化氮合酶 (iNOS) 产生[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ODN 1826 sodium 相关抗体:
体内研究
(In Vivo)

CpG-1826 (100 μg/肿瘤；瘤内注射；每 3 天注射，最多注射 4 次) sodium 可延缓 C57BL/6NTac 小鼠皮下植入的 GL261 神经胶质瘤的生长，诱导巨噬细胞和 B 细胞向肿瘤中的浸润增加，约 50% 的小鼠的生长明显延缓[4]。
ODN 1826 (18 nM；皮下注射；一周 3 次共 7 周) sodium 在慢性血管损伤小鼠模型中增加主动脉粥样硬化斑块大小[5]。
ODN 1826 (0.05 mg；腹腔注射；1，3，5，8，11，13天) sodium 在 Lewis 肺癌小鼠肿瘤模型中具有较强的抗肿瘤生长作用 [6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old male C57BL/6NTac mice; GL261 glioma or B16F10 melanoma subcutaneously implanted in posterior flanks[4].
Dosage: 100 μg/tumor
Administration: Intratumoral injection; every 3 days for up to 4 treatments
Result: Slowed tumor growth, increased F4/80+ macrophages and B220+ B cells in tumors, with variable responses (50% mice showed prolonged stasis) (in GL261 glioma model).
Achieved complete tumor regression and induced long-term immune memory in combination with Cyclophosphamide (HY-17420).
Delayed growth but did not induce regression, with modest increases in F4/80+ macrophages and B220+ B cells in combination with Cyclophosphamide (in B16F10 melanoma model).
分子量

6804.00

同用名

CpG 1826 sodium

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: 99.51%

COA (281 KB) LCMS (374 KB)

产品使用指南 (1538 KB)
参考文献

ODN 1826 sodium 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ODN 1826CpG 1826ODN1826ODN-1826CpG1826CpG-1826Toll-like Receptor (TLR)ApoptosisNO SynthaseNitric oxide synthasesNOSRAW 264.7immunostimulatormurinegliomaLewis lung cancerGL261B16F10 melanomaInhibitorinhibitorinhibit

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ODN 1826 sodium
目录号：
HY-146245C
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