p-Phenetidine  (Synonyms: 对乙氧基苯胺; 4-Ethoxyaniline)

p-Phenetidine (4-Ethoxyaniline) is a metabolite that participates in the oxidation of glutathione (GSH) during peroxidase-catalyzed drug metabolism. p-Phenetidine generates radicals through oxidation, triggering the oxidation of GSH to oxidized glutathione (GSSG) along with significant oxygen consumption. p-Phenetidine can be converted into N-(4-ethoxyphenyl)-p-benzoquinone imine (NEPBQI), which reacts with protein thiols, leading to a decrease in intracellular protein thiols and causing cytotoxicity. p-Phenetidine can be used for drug-induced hepatotoxicity and nephrotoxicity study^[1][2].

137.18

对乙氧基苯胺; 4-Ethoxyaniline

C₈H₁₁NO

156-43-4

液体

Light yellow to brown

对乙氧基苯胺； 对氨基苯乙醚； 4-氨基苯乙醚

Room temperature in continental US; may vary elsewhere.

Store at room temperature 3 years

• [1]. Larsson R, et al. Cellular effects of N(4-ethoxyphenyl)p-benzoquinone imine, a p-phenetidine metabolite formed during peroxidase reactions. Chem Biol Interact. 1986 Dec;60(3):317-30.  [Content Brief]

  [2]. Subrahmanyam VV, et al. Glutathione oxidation during peroxidase catalysed drug metabolism. Chem Biol Interact. 1987 Jan;61(1):45-59.  [Content Brief]