2. Apoptosis Cell Cycle/DNA Damage
  3. MDM-2/p53 Apoptosis Checkpoint Kinase (Chk)
  4. p53 Stabilizer 2

p53 Stabilizer 2 (Compound 17a16) 是一种 p53 稳定剂。p53 Stabilizer 2 可诱导 p53 功能型和 p53 缺陷型癌细胞的 S 期停滞和细胞凋亡 (apoptosis)。p53 Stabilizer 2 可诱导线粒体应激并激活两个免疫检查点通路：NA-PKcs 依赖性 的p53 稳定和 ATR-Chk1 轴的激活。p53 Stabilizer 2 可抑制 p53 缺陷型异种移植瘤模型中的肿瘤生长。

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p53 Stabilizer 2 Chemical Structure

p53 Stabilizer 2 Chemical Structure

CAS No. : 2531685-87-5

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p53 Stabilizer 2 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

生物活性

p53 Stabilizer 2 (Compound 17a16) is a p53 stabilizer. p53 Stabilizer 2 induces S-phase arrest and apoptosis in both p53-proficient and p53-deficient cancer cells. p53 Stabilizer 2 induces mitochondrial stress and activates two checkpoint pathways: NA-PKcs-dependent p53 stabilization and ATR-Chk1 axis activation. p53 Stabilizer 2 inhibits tumor growth in p53-deficient xenograft model[1].

分子量

602.58

Formula

C30H37NO7Se
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

p53 Stabilizer 2 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p53 Stabilizer 22531685-87-5MDM-2/p53ApoptosisCheckpoint Kinase (Chk)p53 stabilizationATR-Chk1 axis activationtumorp53-deficientxenograftInhibitorinhibitorinhibit

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目录号：
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