2. Anti-infection
  3. Influenza Virus
  4. PAN endonuclease-IN-3

PAN endonuclease-IN-3 是一种有效的 PAN 核酸内切酶 (PAN endonuclease) 抑制剂，作用于流感病毒聚合酶复合物的 IC50 为17.4 nM。PAN endonuclease-IN-3 对多种当前不同的流感病毒毒株显示出强大的抗病毒活性，同时在 MDCK 细胞中表现出极低的细胞毒性。PAN endonuclease-IN-3 在 A/WSN/33 感染的小鼠模型中显著抑制病毒复制[1]。

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PAN endonuclease-IN-3 Chemical Structure

PAN endonuclease-IN-3 Chemical Structure

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PAN endonuclease-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PAN endonuclease-IN-3 is a potent PAN endonuclease inhibitor that against influenza virus polymerase complexes with an IC50 of 17.4 nM. PAN endonuclease-IN-3 demonstrates robust antiviral activities against multiple current and different influenza virus strains while showing minimal cytotoxicity in MDCK cells. PAN endonuclease-IN-3 significantly suppresses viral replication in an A/WSN/33 infected mouse model[1].

体外研究
(In Vitro)

PAN endonuclease-IN-3 (Compound 39-(S)) (1-10 μM) 在HEK-293T细胞中表现出 IAV 聚合酶抑制活性，其IC50值为17.4 nM，与Baloxavir (IC50 = 17.8 nM) 的抑制活性相当[1]。

PAN endonuclease-IN-3(1-103 nM)对 PAN 内切酶具有强效抑制作用，其 IC50 值为 41.8 nM[1]。

PAN endonuclease-IN-3 (46 μL/well, 72 h) 在 MDCK 细胞系中显示出卓越的抗病毒活性，EC50 值为 0.21 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PAN endonuclease-IN-3 相关抗体:
体内研究
(In Vivo)

PAN endonuclease-IN-3 (20 mg/kg, 经鼻给药, single dose) 抑制 A/WSN/33 病毒感染小鼠肺部的病毒复制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A/WSN/33 infection model in female BALB/c mice (6-8 weeks old) (1 × 105 TCID50/mouse)
Dosage: 20 mg/kg
Administration: Intranasal administration single dose
Result: Inhibited viral replication.
Maintained normal alveolar structure in the lungs from treated mice.
Reduced infiltration in immune cell.
分子量

511.54

Formula

C26H23F2N3O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PAN endonuclease-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAN endonuclease-IN-3Influenza VirusPAN endonucleaseMDCKA/WSN/33 virusInhibitorinhibitorinhibit

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