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  3. Biochemical Assay Reagents
  4. plCSA-BP

plCSA-BP 是一种胎盘 CSA 结合肽。plCSA-BP 特异性地与滋养层细胞结合，而不会与胎盘中的其他细胞类型或其他组织中表达 CSA 的细胞结合。plCSA-BP 可以引导纳米颗粒将有效载荷 (如 Indocyanine green (ICG) (HY-D0711) 和 Methotrexate (MTX) (HY-14519)) 靶向递送至胎盘，具有胎盘特异性药物递送研究潜力。

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plCSA-BP Chemical Structure

plCSA-BP Chemical Structure

CAS No. : 2294870-89-4

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plCSA-BP 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

plCSA-BP is a Placental CSA-binding peptide. plCSA-BP binds specifically to trophoblasts and not to other cell types in the placenta or to CSA-expressing cells in other tissues. plCSA-BP can guide nanoparticles for the targeted delivery of payloads (such as Indocyanine green (ICG) (HY-D0711) and Methotrexate (MTX) (HY-14519)) to the placenta, promising for placenta-specific drug delivery[1].

体内研究
(In Vivo)

plCSA-BP (50 ng/mL) 在 E6.5、E8.5、E10.5 和 E12.5 时与小鼠胎盘中的滋养层细胞共定位，但不结合胚胎、连接区和蜕膜，对人胎盘也有类似的作用[1]。
plCSA-BP 特异性结合小鼠迷路和人合体滋养层中表达的胎盘型 CSA[1]。
plCSA-BP (5 mg/kg，静脉注射，在 E12.5 或 E15.5 注射一次) 结合纳米颗粒可特异性地将 ICG 递送至 E12.5 或 E15.5 阶段的妊娠小鼠的滋养层细胞[1]。
plCSA-BP (5 mg/kg，静脉注射，从 E6.5 到 E14.5，每隔一天) 结合纳米颗粒可特异性地将 MTX 递送至胎盘细胞，通过靶向胎盘滋养层细胞，导致胎盘和胎儿发育严重受损。[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant CD1 mice (6-8 weeks old)[1].
Dosage: 5 mg/kg (plCSA-BP-conjugated nanoparticle loaded with ICG)
Administration: i.v., once at E12.5 or E15.5.
Result: Induced ICG signal getting to the uterus region 30 min after injection, reaching a peak at 3 h, and maintaining a strong signal upto 12 h in pregnant mice at E12.5.
Induced ICG signal getting to placentas instead of fetuses upto 48 h after injection in pregnant mice at E15.5.
Induced ICG to co-localize with the trophoblast, with little or no signal in endothelial cells in pregnant mice at E12.5.
Animal Model: Pregnant CD1 mice (6-8 weeks old)[1].
Dosage: 1 mg/kg (plCSA-BP-conjugated nanoparticle loaded with MTX)
Administration: i.v., every second day from E6.5 to E14.5, and then collected placenta and other tissues.
Result: Significantly reduced gestational sac length, crown rump length, biparietal diameter, abdominal circumference, placental diameter, and placental thickness.
Notably decreased fetal heart rate and umbilical artery blood flow velocities.
Had a strong cytotoxic effect on both placental and fetal development with decrease of < 10% fetal survival rates, and eliminated labyrinthine region at E14.5.
Inhibited information of embryonic cavities at E8.5 with placenta calcification, and markedly decreased average blood sinusoid areas at E10.5.
Induced pericardial edema and small placentas with high echogenicity and approximately 50% fetuses death at E12.5, and great efficacy of > 90% death at E14.5.
Significantly induced MTX levels accumulation in placentas upto 48 h after injection.
Significantly induced cells apoptosis, mainly belonging to placental labyrinthine trophoblast.
Had minimal liver and kidney toxicity with intact hepatic cords, reduction of inflammatory cells around the central vein, hepatocyte necrosis and activated Kupffer cells.
分子量

3186.61

Formula

C142H221N35O44S2
CAS 号
Sequence

Glu-Asp-Val-Lys-Asp-Ile-Asn-Phe-Asp-Thr-Lys-Glu-Lys-Phe-Leu-Ala-Gly-Cys-Leu-Ile-Val-Ser-Phe-His-Glu-Gly-Lys-Cys
Sequence Shortening

EDVKDINFDTKEKFLAGCLIVSFHEGKC
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

plCSA-BP 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

plCSA-BP2294870-89-4Biochemical Assay ReagentsPeptideChondroitin sulfate ACSATrophoblastMethotrexate (MTX)Indocyanine green (ICG)Inhibitorinhibitorinhibit

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目录号：
HY-P11101
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