2. Others GPCR/G Protein
  3. Isotope-Labeled Compounds LPL Receptor
  4. Ponesimod-d4

Ponesimod-d4  (Synonyms: ACT-128800-d4)

目录号: HY-10569S
产品使用指南

摩尔计算器

Ponesimod-d4 (ACT-128800-d4) 是氘代标记的 Ponesimod (HY-10569)。Ponesimod (ACT-128800) 是一种有效的、选择性的、口服活性的 S1P1 激动剂，在放射性配体结合测定中 IC50 >6 nM。Ponesimod 高效激活 S1P1 介导的信号转导 (EC50=5.7 nM)。Ponesimod 可预防淋巴细胞介导的组织炎症。

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Ponesimod-d<sub>4</sub> Chemical Structure

Ponesimod-d4 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

Other Forms of Ponesimod-d4:

Ponesimod-d4 相关抗体

Top Publications Citing Use of Products

查看 LPL Receptor 亚型特异性产品:

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ponesimod-d4 (ACT-128800-d4)is the deuterium labeledPonesimod(HY-10569)[1]. Ponesimod (ACT-128800) is a potent, selective and orally active agonist of S1P1, with an IC50 of 6 nM in a radioligand binding assay. Ponesimod activates S1P1-mediated signal transduction with high potency (EC50=5.7 nM). Ponesimod can protect against lymphocyte-mediated tissue inflammation[2][3][4].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ponesimod-d4 相关抗体:
分子量

465.00

Formula

C23H21D4ClN2O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ponesimod-d4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ponesimod-d4ACT-128800-d4Isotope-Labeled CompoundsLPL ReceptorLysophospholipid ReceptorInhibitorinhibitorinhibit

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