2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis HSV
  4. Pseudorabies virus-IN-1

Pseudorabies virus-IN-1 是一种有效的 pseudorabies virus (PRV) 抑制剂 (EC50: 0.29 nM), Pseudorabies virus-IN-1 通过靶向 PRV deoxyribonucleic acid polymerase (DNA pol) 来抑制 PRV 复制。Pseudorabies virus-IN-1 在低浓度下即可有效抑制 PRV 复制 (MIC80: 1.6-8 nM)。 Pseudorabies virus-IN-1 可用于 PRV 感染的研究。

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Pseudorabies virus-IN-1 Chemical Structure

Pseudorabies virus-IN-1 Chemical Structure

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Pseudorabies virus-IN-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pseudorabies virus-IN-1 is a potent pseudorabies virus (PRV) inhibitor (EC50: 0.29 nM). Pseudorabies virus-IN-1 inhibits PRV replication by targeting PRV deoxyribonucleic acid polymerase (DNA pol). Pseudorabies virus-IN-1 can effectively inhibit PRV replication at low concentrations (MIC80: 1.6-8 nM). Pseudorabies virus-IN-1 can be used to study PRV infection[1].

体外研究
(In Vitro)

Pseudorabies virus-IN-1 (Compound C2) (0.1-1000 nM, 48 h) 在 PRV (MOI=1) 感染的 PK15 细胞中,极低浓度下即可抑制 50% 的 PRV 复制 (EC50: 0.29 nM)， 表现出显著的活性[1]。
Pseudorabies virus-IN-1 (0.05-100 μM, 72 h) 在 PK15 细胞中具有比较低的细胞毒性(CC50 : 28 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pseudorabies virus-IN-1 相关抗体:
药代动力学
(Parmacokinetics)[1]
Species Dose Route Indicator value
Mice 30 mg/kg i.p. Cmax 342.5 ng/mL
Mice 30 mg/kg i.p. AUC0-t 1022 ng·h/mL
Mice 30 mg/kg i.p. T1/2 3.24 hr
Mice 30 mg/kg i.p. AUC0-t 1326 ng·h/mL
Mice 30 mg/kg i.p. Tmax 1.5 hr
体内研究
(In Vivo)

Pseudorabies virus-IN-1 (Compound C2) (30 mg/kg, i.p. 一天三次，连续七天) 在小鼠脑组织中的病毒载毒量较对照组降低 > 99% (治疗组：2.8×103-2.3×105 copies/g；对照组：9.5×105-1.6×1010 copies/g)[1]。
Pseudorabies virus-IN-1 (30 mg/kg, i.p. 一天三次，连续七天) 使得治疗组小鼠全部存活，而对照组死亡率达 80%，并且治疗组病毒拷贝数显著低于对照组 (约减少 3 倍)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice (female, aged 6-8 weeks) injected with PRV (5 x 107 copies) in 100 µL of PBS[1]
Dosage: 30 mg/kg
Administration: i.p. three times daily for 7 consecutive days
Result: The virus load in brain tissue and plasma was significantly reduced, and no mice died.
分子量

508.95

Formula

C27H23ClF2N4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pseudorabies virus-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pseudorabies virus-IN-1DNA/RNA SynthesisHSVHerpes simplex virusPseudorabies virus (PRV)antivirusDNA polymeraseKunming miceInhibitorinhibitorinhibit

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