2. Epigenetics
  3. Histone Demethylase
  4. Pulrodemstat hydrochloride

Pulrodemstat hydrochloride  (Synonyms: CC-90011 hydrochloride; LSD1-IN-7 hydrochloride)

目录号: HY-129388C
产品使用指南 技术支持

Pulrodemstat (CC-90011) hydrochloride 是一种有效的，选择性的，可逆的和具有口服活性的赖氨酸特异性脱甲基酶-1 (LSD1) 抑制剂，IC50 值为 0.25 nM。Pulrodemstat hydrochloride 对 LSD2，MOA-A 和 MAO-B 的酶抑制作用较小。Pulrodemstat hydrochloride 诱导急性髓细胞性白血病 (AML) 和小细胞肺癌 (SCLC) 细胞分化，并具有有效的抗癌活性。

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Pulrodemstat hydrochloride Chemical Structure

Pulrodemstat hydrochloride Chemical Structure

CAS No. : 1821307-11-2

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Pulrodemstat hydrochloride 的其他形式现货产品:

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Pulrodemstat hydrochloride 相关抗体

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KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pulrodemstat (CC-90011) hydrochloride is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 value of 0.25 nM. Pulrodemstat hydrochloride is less enzymatic inhibition against LSD2, MOA-A, and MAO-B. Pulrodemstat hydrochloride induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity[1].

IC50 & Target

KDM1/LSD1

 

分子量

487.93

同用名

CC-90011 hydrochloride; LSD1-IN-7 hydrochloride

Formula

C24H24ClF2N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pulrodemstat hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pulrodemstat1821307-11-2CC-90011LSD1-IN-7CC90011CC 90011Histone DemethylaseLSD1reversibleoralanticancerdifferentiationSCLCAMLcellInhibitorinhibitorinhibit

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