1. 重组蛋白
  2. Enzymes & Regulators
  3. Hydrolases (EC 3) Angiotensin-converting Enzymes
  4. Angiotensin-Converting Enzyme 2 (ACE2)
  5. ACE2 蛋白, Macaca fascicularis (HEK293, hFc)

ACE2 蛋白, Macaca fascicularis (HEK293, hFc)

目录号: HY-P72029
COA 产品使用指南

ACE2, Macaca fascicularis (HEK 293, hFc) 是一种金属肽酶,可与 SARS-CoV 蛋白的 S1 结构域有效结合。ACE2, Macaca fascicularis 也是心脏功能和血压控制的重要调节剂。

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规格 价格 是否有货 数量
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5 μg ¥1090 In-stock
10 μg ¥1860 In-stock
50 μg ¥5200 In-stock
100 μg   询价  

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  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

  • 参考文献

描述

ACE2, Macaca fascicularis (HEK 293, hFc) is a metallopeptidase which binds effectively to the S1 domain of the SARS‐CoV protein. ACE2, Macaca fascicularis is also an essential regulator of cardiac function and blood pressure control.

研究背景

血管紧张素转换酶 2 (ACE2) 是一种金属肽酶,是 SARS-CoV 的功能受体。ACE2可以被SARS-CoV病毒的S1结构域免疫沉淀,并且ACE2可以促进病毒复制。ACE2 在人类肺和小肠上皮细胞中大量存在,这可能为 SARS-CoV 提供可能的进入途径。ACE2先前被确定为SARS-CoV的细胞受体,也可作为新型冠状病毒(SARS-CoV-2)的受体。ACE2 也被认为是心脏功能和血压控制的重要调节因子,可能是通过充当 ACE1[1][2] 的天然对应物。

生物活性

Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV-2-S1-RBD at 0.2 μg/well can bind Cynomolgus-ACE2, the EC50 is 2.380-10.94 ng/mL.

种属

Cynomolgus

表达系统

HEK293

标签

C-hFc

蛋白编号

A0A2K5X283 (Q18-T741)

基因 ID

102130864  [NCBI]

蛋白结构
N-term
ACE2 (Q18-T741)
Accession # A0A2K5X283
hFc
C-term
同用名
ACE2; Angiotensin-converting enzyme
氨基酸序列

QSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGEKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPNNPQECLLLDPGLNEIMEKSLDYNERLWAWEGWRSEVGKQLRPLYEEYVVLKNEMARANHYKDYGDYWRGNYEVNGVDGYDYNRDQLIEDVERTFEEIKPLYEHLHAYVRAKLMNAYPSYISPTGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVNQAWNAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKVVCHPTAWDLGKGDFRIIMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLLNMLKLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRTYFLEIKHQTILFGEEDVRVADLKPRISFNFYVTAPKNVSDIIPRTEVEEAIRISRSRINDAFRLNDNSLEFLGIQTTLAPPYQSPVTT

分子量

Approximately 116 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US;may vary elsewhere.

文件资料
参考文献
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
ACE2 Protein, Macaca fascicularis (HEK293, hFc)
目录号:
HY-P72029
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