Aldose-reductase 蛋白, Human

The Aldose-reductase protein reduces carbonyl-containing compounds to alcohols, including retinals. It detoxifies unsaturated carbonyls like crotonaldehyde and 4-hydroxynonenal, but lacks reductase activity towards glucose. Aldose-reductase Protein, Human is the recombinant human-derived Aldose-reductase protein, expressed by E. coli , with tag free. The total length of Aldose-reductase Protein, Human is 316 a.a., .

醛糖还原酶是一种多功能酶，可催化多种含羰基化合物的 NADPH 依赖性还原，将其转化为相应的醇。值得注意的是，它对各种视网膜异构体表现出强大的酶活性，包括全反式视黄醛、9-顺式视黄醛和13-顺式视黄醛。该酶在来自饮食和脂质的不饱和羰基的解毒中发挥着关键作用，例如巴豆醛、4-羟基壬烯醛、反式-2-己烯醛、反式-2,4-己二烯醛及其谷胱甘肽缀合物羰基（GS-羰基）。值得注意的是，尽管醛糖还原酶具有广泛的底物特异性，但它对葡萄糖不表现出还原酶活性。这种多样化的催化功能凸显了其在细胞解毒过程中的重要性，并强调了其在解决氧化应激相关病症方面的潜在治疗意义。

Human

E. coli

Tag Free

O60218 (M1-Y316)

57016

Approximately 36 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, 200 mM NaCl, 20% glycerol, 1 mM DTT, pH 7.5.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.