AP-2 gamma/TFAP2C 蛋白, Human (His)

The AP-2 gamma/TFAP2C protein is a sequence-specific DNA-binding factor that complexly regulates gene transcription by binding to enhancer elements. It recognizes the consensus sequence 5'-GCCNNNGGC-3' and activates genes critical for multiple developmental functions. AP-2 gamma/TFAP2C Protein, Human (His) is the recombinant human-derived AP-2 gamma/TFAP2C protein, expressed by E. coli , with N-His labeled tag. The total length of AP-2 gamma/TFAP2C Protein, Human (His) is 96 a.a., with molecular weight of 12-14 kDa.

AP-2 gamma/TFAP2C 蛋白作为序列特异性 DNA 结合因子，与诱导型病毒和细胞增强子元件结合，复杂地调节特定基因的转录。AP-2 gamma 识别共有序列 5'-GCCNNNGGC-3'，激活对多种生物功能至关重要的基因，涵盖眼睛、面部、体壁、四肢和神经管发育。同时，它对多个基因产生抑制作用，包括 MCAM/MUC18、C/EBP α 和 MYC。该蛋白还在乳腺癌中 MTA1 介导的 ESR1 表达的表观遗传控制中发挥着关键作用。作为二聚体，AP-2 γ 可以与 AP-2 家族的其他成员形成同二聚体或异二聚体。值得注意的是，它参与各种蛋白质相互作用，包括与 WWOX、CITED4、UBE2I、KCTD1、CITED2 和 MTA1 的相互作用，每种蛋白质都有助于控制转录活性的复杂调控网络。

Human

E. coli

N-10*His

Q92754-1 (L128-V223)

7022  [NCBI]

LSGLEAGAVSARRDAYRRSDLLLPHAHALDAAGLAENLGLHDMPHQMDEVQNVDDQHLLLHDQTVIRKGPISMTKNPLNLPCQKELVGAVMNPTEV

Approximately 10-14 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.